There are 6 ways to get from Knoxville to Illinois by plane, bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Mcghee Tyson Airport to Chicago Midway International Airport
best- Fly from Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW)plane TYS - MDW
2h 31m$119–452Drive to Chattanooga Metropolitan Airport, fly to Chicago O'Hare International Airport
cheapest- Drive from Knoxville to Chattanooga Metropolitan Airport (CHA)car
- Fly from Chattanooga Metropolitan Airport (CHA) to Chicago O'Hare International Airport (ORD)plane CHA - ORD
4h 41m$65–311Bus
- Take the bus from Knoxville to Nashvillebus Nyc
- Take the bus from Nashville Bus Station to Chicago Bus Stationbus Greyhound US0100
14h 54m$208–299Drive 527.1 mi
- Drive from Knoxville to Chicagocar 527.1 mi
9h 13m$94–135Fly Mcghee Tyson Airport to Chicago O'Hare International Airport
- Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane TYS - ORD
3h 8m$104–342Drive to Asheville Regional Airport, fly to Chicago O'Hare International Airport
- Drive from Knoxville to Asheville-Airport-AVLcar
- Fly from Asheville Regional Airport (AVL) to Chicago O'Hare International Airport (ORD)plane AVL - ORD
5h 7m$68–316
Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW) flights
Comparing Your Travel Options
The cheapest way to get from Knoxville to Illinois is to drive which costs $90 - $140 and takes 9h 13m.
The fastest way to get from Knoxville to Illinois is to fly which takes 2h 31m and costs $110 - $460.
No, there is no direct bus from Knoxville to Illinois station. However, there are services departing from Knoxville and arriving at Chicago Bus Station via Charlotte Pike & Lellyett St Eb, Central 4Th Ave - Bay 13 and Nashville Bus Station. The journey, including transfers, takes approximately 14h 54m.
The distance between Knoxville and Illinois is 486 miles. The road distance is 530.2 miles.
The best way to get from Knoxville to Illinois without a car is to bus which takes 14h 54m and costs $200 - $300.
It takes approximately 2h 31m to get from Knoxville to Illinois, including transfers.
Knoxville to Illinois bus services, operated by Wanda Coach, depart from Knoxville station.
The best way to get from Knoxville to Illinois is to fly which takes 2h 31m and costs $110 - $460. Alternatively, you can bus, which costs $200 - $300 and takes 14h 54m.
Knoxville to Illinois bus services, operated by Wanda Coach, arrive at Nashville station.
Illinois is 1h behind Knoxville. It is currently 4:44 PM in Knoxville and 3:44 PM in Illinois.
What companies run services between Knoxville, TN, USA and Illinois, USA?
Allegiant Air, Southwest Airlines, and Delta fly from Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW) once daily. Alternatively, you can take a vehicle from Knoxville to Chicago Bus Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville Bus Station in around 14h 54m.
- Website
- aa.com
Flights from Mcghee Tyson Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 10m
- When
- Every day
- Estimated price
- $45–270
Flights from Mcghee Tyson Airport to Chicago O'Hare International Airport via Charlotte
- Ave. Duration
- 4h 50m
- When
- Every day
- Estimated price
- $60–320
Flights from Chattanooga Metropolitan Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 19m
- When
- Every day
- Estimated price
- $45–280
Flights from Chattanooga Metropolitan Airport to Chicago O'Hare International Airport via Charlotte
- Ave. Duration
- 5h 1m
- When
- Every day
- Estimated price
- $60–320
Flights from Asheville Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 15m
- When
- Every day
- Estimated price
- $45–280
Flights from Asheville Regional Airport to Chicago O'Hare International Airport via Charlotte
- Ave. Duration
- 4h 54m
- When
- Every day
- Estimated price
- $55–300
- Website
- united.com
Flights from Mcghee Tyson Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 6m
- When
- Every day
- Estimated price
- $45–270
Flights from Mcghee Tyson Airport to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 5h
- When
- Tuesday to Sunday
- Estimated price
- $70–350
Flights from Chattanooga Metropolitan Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 10m
- When
- Every day
- Estimated price
- $45–280
Flights from Asheville Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 17m
- When
- Every day
- Estimated price
- $45–280
- Website
- delta.com
Flights from Mcghee Tyson Airport to Chicago Midway International Airport via Atlanta
- Ave. Duration
- 3h 54m
- When
- Every day
- Estimated price
- $80–430
Flights from Mcghee Tyson Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 4h 12m
- When
- Sunday
- Estimated price
- $55–300
Flights from Mcghee Tyson Airport to Chicago O'Hare International Airport via Atlanta
- Ave. Duration
- 4h 47m
- When
- Every day
- Estimated price
- $55–310
Flights from Chattanooga Metropolitan Airport to Chicago O'Hare International Airport via Atlanta
- Ave. Duration
- 4h 23m
- When
- Every day
- Estimated price
- $55–310
Flights from Chattanooga Metropolitan Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- $55–310
Flights from Asheville Regional Airport to Chicago O'Hare International Airport via Atlanta
- Ave. Duration
- 4h 44m
- When
- Every day
- Estimated price
- $60–320
- Website
- allegiantair.com
Flights from Mcghee Tyson Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 32m
- When
- Monday and Friday
- Estimated price
- $60–380
- Website
- southwest.com
Flights from Mcghee Tyson Airport to Chicago Midway International Airport via Nashville
- Ave. Duration
- 3h 45m
- When
- Wednesday
- Estimated price
- $65–390
- Phone
- +1 646-630-7186
- [email protected]
- Website
- Wanda Coach
Bus from Knoxville to Nashville
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $40–60
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $40–60
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Nashville Bus Station to Chicago Bus Station
- Ave. Duration
- 10h
- Frequency
- 4 times a day
- Estimated price
- $85–130
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Nashville Bus Station to Chicago Bus Station
- Ave. Duration
- 11h 25m
- Frequency
- 3 times a day
- Estimated price
- $75–120
- Schedules at
- Flixbus USA
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Booking & Getting There
Yes, the driving distance between Knoxville to Illinois is 530 miles. It takes approximately 9h 13m to drive from Knoxville to Illinois.
There are 1304+ hotels available in Illinois.



