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How to get fromKnoxville to Indianaby plane, bus (Greyhound, Amtrak), car, or train

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There are 5 ways to get from Knoxville to Indiana by plane, bus (Greyhound, Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Evansville

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Evansville (EVV)plane plane TYS - EVV
    4h 11m
    $136–450

  2. Drive  347.6 mi

    cheapest
    1. Drive from Knoxville to Indianapoliscar car 347.6 mi
    6h 2m
    $60–86

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    10h 49m
    $178–224

  4. Fly to Chicago Midway International Airport, train

    1. Fly from Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW)plane plane TYS - MDW
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    3h 44m
    $127–462

  5. Fly to Chicago O'Hare International Airport, train

    1. Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane plane TYS - ORD
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    4h 19m
    $112–352

Mcghee Tyson Airport (TYS) to Evansville (EVV) flights

Calendar66Weekly Planes
Duration5h 5mAverage Duration
Ticket$61Cheapest Price
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Comparing Your Travel Options

Map of how to get from Knoxville to Indiana.ExpandLaunch map view
  • Distance: 268.8 mi
  • Duration: 4h 11m

What companies run services between Knoxville, TN, USA and Indiana, USA?

Delta and American Airlines fly from Mcghee Tyson Airport (TYS) to Evansville (EVV) every 3 hours. Alternatively, you can take a vehicle from Knoxville to Indianapolis Union Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville Bus Station in around 10h 49m.

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