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How to get fromKnoxville to Iowaby plane, bus, train, car, or bus (Greyhound)

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There are 8 ways to get from Knoxville to Iowa by plane, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Omaha

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Omaha (OMA)plane plane TYS - OMA
    4h 23m
    $212–797

  2. Drive 814.1 mi

    cheapest
    1. Drive from Knoxville to Des Moinescar car 814.1 mi
    13h 57m
    $149–215

  3. Bus, train

    1. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    2. Take the bus from Memphis Bus Station to St Louis Bus Stationbus bus
    3. Take the train from St. Louis to Kansas Citytrain train
    4. Take the bus from Kansas City to Des Moinesbus bus
    25h 15m
    $344–570

  4. Fly to Des Moines

    1. Fly from Mcghee Tyson Airport (TYS) to Des Moines (DSM)plane plane TYS - DSM
    4h 41m
    $234–938

  5. Fly to The Eastern Iowa Airport

    1. Fly from Mcghee Tyson Airport (TYS) to The Eastern Iowa Airport (CID)plane plane TYS - CID
    4h 44m
    $192–617

  6. Fly to Waterloo Municipal Airport

    1. Fly from Mcghee Tyson Airport (TYS) to Waterloo Municipal Airport (ALO)plane plane TYS - ALO
    5h 8m
    $170–640

  7. Fly to Quad City International Airport

    1. Fly from Mcghee Tyson Airport (TYS) to Quad City International Airport (MLI)plane plane TYS - MLI
    5h 57m
    $149–559

  8. Bus

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    26h 1m
    $323–457

Mcghee Tyson Airport (TYS) to Omaha (OMA) flights

Calendar93Weekly Planes
Duration5h 45mAverage Duration
Ticket$132Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Iowa.ExpandLaunch map view
  • Distance: 766.6 mi
  • Duration: 4h 23m

What companies run services between Knoxville, TN, USA and Iowa, USA?

Southwest Airlines, Delta, and two other airlines fly from Mcghee Tyson Airport (TYS) to Omaha (OMA) hourly. Alternatively, you can take a vehicle from Knoxville to Des Moines via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, Indianapolis, Indianapolis Union Station, and Des Moines in around 26h 1m.

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