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How to get fromKnoxville to Iowaby plane, bus (Greyhound), car, bus, or train

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There are 10 ways to get from Knoxville to Iowa by plane, bus (Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Omaha

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Omaha (OMA)plane plane TYS - OMA
    4h 23m
    $212–797

  2. Drive 814.1 mi

    cheapest
    1. Drive from Knoxville to Des Moinescar car 814.1 mi
    13h 57m
    $149–215

  3. Bus via Indianapolis

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Central 5Th Ave - Bay 11 to Clarksville Exit 11 Park And Ridebus bus 94
    3. Take the bus from Clarksville Park & Ride to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    23h 55m
    $256–405

  4. Fly to Des Moines

    1. Fly from Mcghee Tyson Airport (TYS) to Des Moines (DSM)plane plane TYS - DSM
    4h 41m
    $244–988

  5. Fly to The Eastern Iowa Airport

    1. Fly from Mcghee Tyson Airport (TYS) to The Eastern Iowa Airport (CID)plane plane TYS - CID
    4h 28m
    $192–667

  6. Fly to Waterloo Municipal Airport

    1. Fly from Mcghee Tyson Airport (TYS) to Waterloo Municipal Airport (ALO)plane plane TYS - ALO
    5h 8m
    $175–640

  7. Fly to Quad City International Airport

    1. Fly from Mcghee Tyson Airport (TYS) to Quad City International Airport (MLI)plane plane TYS - MLI
    5h 57m
    $149–569

  8. Bus, train

    1. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    2. Take the bus from Memphis Bus Station to St Louis Bus Stationbus bus
    3. Take the train from St. Louis to Kansas Citytrain train
    4. Take the bus from Kansas City to Des Moinesbus bus
    24h 25m
    $367–591

  9. Bus

    1. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    2. Take the bus from Memphis Bus Station to Kansas Citybus bus
    3. Take the bus from Kansas City to Des Moinesbus bus
    24h 53m
    $313–432

  10. Bus #2

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    26h 59m
    $299–533

Mcghee Tyson Airport (TYS) to Omaha (OMA) flights

Calendar102Weekly Planes
Duration5h 35mAverage Duration
Ticket$135Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Iowa.ExpandLaunch map view
  • Distance: 766.6 mi
  • Duration: 4h 23m

What companies run services between Knoxville, TN, USA and Iowa, USA?

Southwest Airlines, Delta, and two other airlines fly from Mcghee Tyson Airport (TYS) to Omaha (OMA) hourly. Alternatively, you can take a vehicle from Knoxville to Des Moines via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 5Th Ave - Bay 11, Clarksville Exit 11 Park And Ride, Clarksville Park & Ride, Indianapolis Union Station, and Des Moines in around 23h 55m.

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