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How to get fromKnoxville to Ithacaby plane, bus, train, car, shuttle, or taxi

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There are 8 ways to get from Knoxville to Ithaca by plane, bus, train, car, shuttle, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Ithaca Tompkins Regional Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Ithaca Tompkins Regional Airport (ITH)plane plane TYS - ITH
    5h 31m
    $147–567

  2. Drive  711.1 mi

    cheapest
    1. Drive from Knoxville to Ithacacar car 711.1 mi
    13h 2m
    $130–188

  3. Bus, train

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from New York Penn Station to Syracusetrain train
    3. Take the bus from Syracuse Bus Station to Ithacabus bus
    21h 17m
    $224–418

  4. Fly to Greater Binghamton Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Greater Binghamton Airport (BGM)plane plane TYS - BGM
    2. Take the bus from Binghamton to Ithacabus bus
    8h 56m
    $208–697

  5. Fly to Elmira/Corning Regional Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Elmira/Corning Regional Airport (ELM)plane plane TYS - ELM
    2. Take the bus from Transit Center - PO Side to Tompkins County Librarybus bus
    8h 43m
    $162–626

  6. Fly to Syracuse Hancock International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Syracuse Hancock International Airport (SYR)plane plane TYS - SYR
    2. Take the bus from Syracuse Bus Station to Ithacabus bus
    7h 18m
    $269–1,209

  7. Bus

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the bus from New York to Ithacabus bus Adt N806-D / ...
    21h 25m
    $141–287

  8. Drive, shuttle, taxi, bus

    1. Drive from Knoxville to Hot Springscar car
    2. Take a shuttle bus from Hot Springs to Black Bear Resortshuttle bus
    3. Take the taxi from Black Bear Resort to Bristol Exit 5 Park & Ride Lottaxi taxi
    4. Take the bus from Bristol Exit 5 Park & Ride Lot to Washington Union Stationbus bus
    5. Take the bus from Washington Union Station to Ithacabus bus
    23h 38m
    $369–460

Mcghee Tyson Airport (TYS) to Ithaca Tompkins Regional Airport (ITH) flights

Calendar21Weekly Planes
Duration4h 23mAverage Duration
Ticket$92Cheapest Price
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Comparing Your Travel Options

Map of how to get from Knoxville to Ithaca.ExpandLaunch map view
  • Distance: 632.5 mi
  • Duration: 5h 31m

What companies run services between Knoxville, TN, USA and Ithaca, NY, USA?

United Airlines and Allegiant Air fly from Mcghee Tyson Airport (TYS) to Ithaca Tompkins Regional Airport (ITH) 3 times a day. Alternatively, you can take a bus from Knoxville Station Bay H to Ithaca via Fountain City Superstop, Walmart, Knoxville, TN, New York, NY, Canal St, 42 St-Times Square, and New York in around 21h 25m.

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