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How to get fromKnoxville to Jefferson Cityby plane, bus, train, car, shuttle, or bus (Greyhound, Flixbus)

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There are 5 ways to get from Knoxville to Jefferson City by plane, bus, train, car, shuttle, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Columbia Regional Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Columbia Regional Airport (COU)plane plane TYS - COU
    5h 32m
    $257–777

  2. Drive 578.6 mi

    cheapest
    1. Drive from Knoxville to Jefferson Citycar car 578.6 mi
    10h 50m
    $106–153

  3. Bus, train

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    3. Take the train from St. Louis to Jefferson City Stationtrain train
    14h 59m
    $213–339

  4. Fly to Lambert–St. Louis International Airport, shuttle

    1. Fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL)plane plane TYS - STL
    2. Take a shuttle bus from St Louis International Airport to Jefferson City, Missourishuttle bus
    6h 27m
    $302–917

  5. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Jefferson Citybus bus
    16h 43m
    $211–320

Mcghee Tyson Airport (TYS) to Columbia Regional Airport (COU) flights

Calendar53Weekly Planes
Duration5h 44mAverage Duration
Ticket$118Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Jefferson City.ExpandLaunch map view
  • Distance: 532.4 mi
  • Duration: 5h 32m

What companies run services between Knoxville, TN, USA and Jefferson City, MO, USA?

United Airlines and American Airlines fly from Mcghee Tyson Airport (TYS) to Columbia Regional Airport (COU) every 4 hours. Alternatively, you can take a vehicle from Knoxville to Jefferson City via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, St Louis Bus Station, and Jefferson City in around 16h 43m.

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