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How to get fromKnoxville to Key Westby plane, bus (Greyhound, Flixbus), car, shuttle, taxi, bus, train, or ferry

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There are 7 ways to get from Knoxville to Key West by plane, bus (Greyhound, Flixbus), car, shuttle, taxi, bus, train, or ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Mcghee Tyson Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Key West International Airport (EYW)plane plane TYS - EYW
    2h 26m
    $143–470

  2. Drive to Asheville Regional Airport, fly

    cheapest
    1. Drive from Knoxville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane plane AVL - EYW
    4h 18m
    $93–375

  3. Bus

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to El Mercadito Grocery - Clarksville, INbus bus
    3. Take the bus from Louisville Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    6. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    43h 43m
    $404–608

  4. Drive, shuttle, taxi, bus, train

    1. Drive from Knoxville to Hot Springscar car
    2. Take a shuttle bus from Hot Springs to Black Bear Resortshuttle bus
    3. Take the taxi from Black Bear Resort to Bristol Exit 5 Park & Ride Lottaxi taxi
    4. Take the bus from Bristol Exit 5 Park & Ride Lot to Washington Union Stationbus bus
    5. Take the train from Washington Union Station to Hollywood Amtrak Stationtrain train
    6. Take the bus from Miami Airport Station to Big Pine Keybus bus
    7. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    44h 39m
    $608–1,085

  5. Drive  997.8 mi

    1. Drive from Knoxville to Key Westcar car 997.8 mi
    18h 12m
    $183–263

  6. Bus, ferry

    1. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    2. Take the bus from Memphis Bus Station to Baton Rouge Bus Stationbus bus
    3. Take the bus from Baton Rouge to Fort Myersbus bus
    4. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    44h 12m
    $542–713

  7. Bus, train

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    2d 1h
    $540–1,026

Mcghee Tyson Airport (TYS) to Key West International Airport (EYW) flights

Calendar35Weekly Planes
Duration4hAverage Duration
Ticket$75Cheapest Price
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Comparing Your Travel Options

Map of how to get from Knoxville to Key West.ExpandLaunch map view
  • Distance: 803.2 mi
  • Duration: 2h 26m

What companies run services between Knoxville, TN, USA and Key West, FL, USA?

Allegiant Air, Delta, and American Airlines fly from Mcghee Tyson Airport (TYS) to Key West International Airport (EYW) 5 times a day. Alternatively, you can take a vehicle from Knoxville to N Roosevelt & 3rd Street via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, El Mercadito Grocery - Clarksville, IN, Louisville Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 43h 43m.

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