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How to get fromKnoxville to Key West (Island)by plane, bus (Greyhound, Flixbus), or car

Find Transport to Key West (Island)

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There are 5 ways to get from Knoxville to Key West (Island) by plane, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Mcghee Tyson Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Key West International Airport (EYW)plane plane TYS - EYW
    2h 28m
    $152–537

  2. Drive to Asheville Regional Airport, fly

    cheapest
    1. Drive from Knoxville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane plane AVL - EYW
    4h 17m
    $87–362

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Key West Airportbus bus
    30h 8m
    $292–504

  4. Drive 997.8 mi

    1. Drive from Knoxville to Key Westcar car 997.8 mi
    18h 12m
    $183–263

  5. Drive to Chattanooga Metropolitan Airport, fly

    1. Drive from Knoxville to Chattanooga Metropolitan Airport (CHA)car car
    2. Fly from Chattanooga Metropolitan Airport (CHA) to Key West International Airport (EYW)plane plane CHA - EYW
    5h 34m
    $119–577

Mcghee Tyson Airport (TYS) to Key West International Airport (EYW) flights

Calendar25Weekly Planes
Duration4h 32mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Key West (Island).ExpandLaunch map view
  • Distance: 801.2 mi
  • Duration: 2h 28m

What companies run services between Knoxville, TN, USA and Key West (Island), FL, USA?

Allegiant Air, Delta, and American Airlines fly from Mcghee Tyson Airport (TYS) to Key West International Airport (EYW) 4 times a day. Alternatively, you can take a vehicle from Knoxville to Key West Airport via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, Atlanta Bus Station, and Miami Airport Station in around 30h 8m.

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