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How to get fromKnoxville to Lafayetteby plane, bus (Amtrak), car, shuttle, bus, or train

Find Transport to Lafayette

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There are 5 ways to get from Knoxville to Lafayette by plane, bus (Amtrak), car, shuttle, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Purdue University Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Purdue University Airport (LAF)plane plane TYS - LAF
    6h 35m
    $153–618

  2. Drive 409.3 mi

    cheapest
    1. Drive from Knoxville to Lafayettecar car 409.3 mi
    7h 11m
    $75–108

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville to Lafayette Amtrak Stationbus bus
    12h 14m
    $183–239

  4. Fly to Indianapolis, shuttle

    1. Fly from Mcghee Tyson Airport (TYS) to Indianapolis (IND)plane plane TYS - IND
    2. Take a shuttle bus from Indianapolis Airport to Holiday Inn City Centreshuttle bus
    5h 14m
    $171–752

  5. Bus, train

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Indianapolis Union Stationbus bus
    3. Take the train from Indianapolis to Lafayette Amtrak Stationtrain train
    13h 25m
    $201–274

Mcghee Tyson Airport (TYS) to Purdue University Airport (LAF) flights

Calendar47Weekly Planes
Duration7h 40mAverage Duration
Ticket$95Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Lafayette.ExpandLaunch map view
  • Distance: 371.6 mi
  • Duration: 6h 35m

What companies run services between Knoxville, TN, USA and Lafayette, IN, USA?

United Airlines and American Airlines fly from Mcghee Tyson Airport (TYS) to Purdue University Airport (LAF) every 4 hours. Alternatively, you can take a vehicle from Knoxville to Lafayette Amtrak Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville in around 12h 14m.

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