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How to get fromKnoxville to Lancasterby plane, bus, train, car, or bus (Flixbus)

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There are 7 ways to get from Knoxville to Lancaster by plane, bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Mcghee Tyson Airport to Harrisburg International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Harrisburg International Airport (MDT)plane plane TYS - MDT
    8h 11m
    $153–581

  2. Drive 553.8 mi

    cheapest
    1. Drive from Knoxville to Lancastercar car 553.8 mi
    9h 50m
    $102–146

  3. Bus, train

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Elizabethtown Amtrak Stationtrain train Keystone Service / ...
    18h 42m
    $195–283

  4. Fly Mcghee Tyson Airport to Philadelphia International Airport, train

    1. Fly from Mcghee Tyson Airport (TYS) to Philadelphia International Airport (PHL)plane plane TYS - PHL
    2. Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain train
    7h 16m
    $217–830

  5. Fly Mcghee Tyson Airport to Baltimore-Washington International Airport, train

    1. Fly from Mcghee Tyson Airport (TYS) to Baltimore-Washington International Airport (BWI)plane plane TYS - BWI
    2. Take the train from BWI Thurgood Marshall to 30th Street Stationtrain train
    3. Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain train
    8h 43m
    $208–1,379

  6. Drive to Asheville Regional Airport, fly to Philadelphia International Airport, train

    1. Drive from Knoxville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Philadelphia International Airport (PHL)plane plane AVL - PHL
    3. Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain train
    9h 10m
    $132–565

  7. Bus

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the bus from New York City Chinatown to Harrisburg Bus Stationbus bus FlixBus N2640
    24h 16m
    $138–186

Mcghee Tyson Airport (TYS) to Harrisburg International Airport (MDT) flights

Calendar118Weekly Planes
Duration4h 49mAverage Duration
Ticket$90Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Lancaster.ExpandLaunch map view
  • Distance: 559.5 mi
  • Duration: 8h 11m

What companies run services between Knoxville, TN, USA and Lancaster, PA, USA?

United Airlines, American Airlines, and two other airlines fly from Mcghee Tyson Airport (TYS) to Harrisburg International Airport (MDT) hourly. Alternatively, you can take a bus from Knoxville Station Bay H to W. Chestnut & Water St. via Fountain City Superstop, Walmart, Knoxville, TN, New York City Chinatown, Harrisburg Bus Station, Harrisburg, Elizabethtown Amtrak Station, and AMTRAK ETown in around 24h 16m.

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