There are 6 ways to get from Knoxville to Lewes by plane, taxi, car, shuttle, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Salisbury–Ocean City–Wicomico Regional Airport, taxi
best- Fly from Mcghee Tyson Airport (TYS) to Salisbury–Ocean City–Wicomico Regional Airport (SBY)plane TYS - SBY
- Take the taxi from Salisbury–Ocean City–Wicomico Regional Airport (SBY) to Lewestaxi
5h 26m$287–837Drive 588 mi
cheapest- Drive from Knoxville to Lewescar 588 mi
10h 55m$108–155Drive, shuttle, taxi, bus, train
- Drive from Knoxville to Hot Springscar
- Take a shuttle bus from Hot Springs to Black Bear Resort
- Take the taxi from Black Bear Resort to Bristol Exit 5 Park & Ride Lottaxi
- Take the bus from Bristol Exit 5 Park & Ride Lot to Washington Union Stationbus
- Take the train from Washington Union Station to Wilmingtontrain
- Take the bus from Wilmington Tc to Lewes Transit Centerbus 305
17h 56m$324–1,000Fly to Philadelphia International Airport, shuttle
- Fly from Mcghee Tyson Airport (TYS) to Philadelphia International Airport (PHL)plane TYS - PHL
- Take a shuttle bus from Philadelphia Airport to Lewes Transit Center
5h 58m$248–840Bus, train
- Take the bus from Knoxville, TN to New York, NYbus Ny
- Take the train from Ny Moynihan Train Hall At Penn Station to Wilmingtontrain
- Take the bus from Wilmington Tc to Lewes Transit Centerbus 305
18h 31m$172–823Drive, shuttle, taxi, bus, train via Roanoke
- Drive from Knoxville to Hot Springscar
- Take a shuttle bus from Hot Springs to Black Bear Resort
- Take the taxi from Black Bear Resort to Bristol Exit 5 Park & Ride Lottaxi
- Take the bus from Bristol Exit 5 Park & Ride Lot to Christiansburgbus
- Take the bus from Exit 118 - Park and Ride to Roanoke Campbell Courtbus Swb
- Take the train from Roanoke to Wilmingtontrain
- Take the bus from Wilmington Tc to Lewes Transit Centerbus 305
20h 47m$376–539
Mcghee Tyson Airport (TYS) to Salisbury–Ocean City–Wicomico Regional Airport (SBY) flights
Questions & Answers
The cheapest way to get from Knoxville to Lewes is to drive which costs $100 - $160 and takes 10h 55m.
The fastest way to get from Knoxville to Lewes is to fly and taxi which takes 5h 26m and costs $280 - $850.
The distance between Knoxville and Lewes is 555 miles. The road distance is 591.5 miles.
The best way to get from Knoxville to Lewes without a car is to bus and train which takes 18h 31m and costs $170 - $850.
It takes approximately 5h 26m to get from Knoxville to Lewes, including transfers.
Yes, the driving distance between Knoxville to Lewes is 591 miles. It takes approximately 10h 55m to drive from Knoxville to Lewes.
There are 391+ hotels available in Lewes.
What companies run services between Knoxville, TN, USA and Lewes, DE, USA?
There is no direct connection from Knoxville to Lewes. However, you can take the taxi to Mcghee Tyson Airport (TYS) airport, fly to Salisbury–Ocean City–Wicomico Regional Airport (SBY), then take the taxi to Lewes. Alternatively, you can drive to Hot Springs, take the shuttle to Black Bear Resort, take the taxi to Bristol Exit 5 Park & Ride Lot, take the bus to Washington Union Station, walk to Washington Union Station, take the train to Wilmington, walk to Wilmington Tc, take the bus to Lewes Transit Center, then take the line 204 bus to Savannah Rd @ 3Rd St.
- Website
- aa.com
Flights from Mcghee Tyson Airport to Salisbury–Ocean City–Wicomico Regional Airport via Charlotte
- Ave. Duration
- 4h 13m
- When
- Every day
- Estimated price
- $100–600
Flights from Mcghee Tyson Airport to Salisbury–Ocean City–Wicomico Regional Airport via Philadelphia International Airport
- Ave. Duration
- 4h 26m
- When
- Every day
- Estimated price
- $110–650
Flights from Mcghee Tyson Airport to Philadelphia International Airport
- Ave. Duration
- 2h
- When
- Every day
- Estimated price
- $120–700
Flights from Mcghee Tyson Airport to Philadelphia International Airport via Reagan Washington
- Ave. Duration
- 3h 55m
- When
- Every day
- Estimated price
- $120–700
Flights from Mcghee Tyson Airport to Philadelphia International Airport via Charlotte
- Ave. Duration
- 4h 18m
- When
- Every day
- Estimated price
- $120–700
- Website
- delta.com
Flights from Mcghee Tyson Airport to Philadelphia International Airport via Atlanta
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $150–800
- Website
- southwest.com
Flights from Mcghee Tyson Airport to Philadelphia International Airport via Nashville
- Ave. Duration
- 4h 5m
- When
- Sunday, Tuesday, and Wednesday
- Estimated price
- $150–800
- Website
- flybreeze.com
Flights from Mcghee Tyson Airport to Salisbury–Ocean City–Wicomico Regional Airport via Orlando
- Ave. Duration
- 5h 3m
- When
- Monday and Friday
- Estimated price
- $320–1,600
- Website
- allegiantair.com
Flights from Mcghee Tyson Airport to Philadelphia International Airport
- Ave. Duration
- 1h 50m
- When
- Monday and Friday
- Estimated price
- $120–700
- Website
- united.com
Flights from Mcghee Tyson Airport to Philadelphia International Airport via Washington Dulles
- Ave. Duration
- 3h 58m
- When
- Monday, Thursday, Friday, and Saturday
- Estimated price
- $120–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Washington Union Station to Wilmington
- Ave. Duration
- 1h 21m
- Frequency
- Hourly
- Estimated price
- $30–70
- Website
- Amtrak
Train from Ny Moynihan Train Hall At Penn Station to Wilmington
- Ave. Duration
- 1h 58m
- Frequency
- Hourly
- Estimated price
- $35–80
- Website
- Amtrak
Train from Roanoke to Wilmington
- Ave. Duration
- 7h 15m
- Frequency
- Twice daily
- Estimated price
- $100–220
- Website
- Amtrak
Rome2Rio's guide to Amtrak Acela
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Washington Union Station to Wilmington
- Ave. Duration
- 1h 16m
- Frequency
- Every 3 hours
- Estimated price
- $24–650
- Schedules at
- Amtrak Acela
- Website
- Amtrak
- Business Class
- $24–460
- First Class
- $140–650
Train from Ny Moynihan Train Hall At Penn Station to Wilmington
- Ave. Duration
- 1h 35m
- Frequency
- Every 2 hours
- Estimated price
- $26–650
- Schedules at
- Amtrak Acela
- Website
- Amtrak
- Business Class
- $26–460
- First Class
- $140–650
- Phone
- +1-423-725-5988
- Website
- Black Bear Resort Shuttle
Shuttle from Hot Springs to Black Bear Resort
- Ave. Duration
- 1h 30m
- Frequency
- On demand
- Estimated price
- $136
- Website
- Black Bear Resort Shuttle
Shuttle from Hot Springs to Black Bear Resort
- Ave. Duration
- 1h 30m
- Frequency
- On demand
- Estimated price
- $136
- Website
- Black Bear Resort Shuttle
- Phone
- +1-800-827-3490
- [email protected]
- Website
- Virginia Breeze
Bus from Bristol Exit 5 Park & Ride Lot to Washington Union Station
- Ave. Duration
- 7h 45m
- Frequency
- Once daily
- Estimated price
- $50–65
- Schedules at
- Virginia Breeze
Bus from Bristol Exit 5 Park & Ride Lot to Christiansburg
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $25–30
- Schedules at
- Virginia Breeze
- Phone
- +1 800-652-3278
- Website
- DART
Bus from Wilmington Tc to Lewes Transit Center
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $5–7
- Website
- DART
Bus from Wilmington Tc to Lewes Transit Center
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $5–7
- Website
- DART
Bus from Wilmington Tc to Lewes Transit Center
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $5–7
- Website
- DART
- Phone
- +1 302-470-6784
- [email protected]
- Website
- Lewes Bus
Shuttle from Philadelphia Airport to Lewes Transit Center
- Ave. Duration
- 2h
- Frequency
- Twice daily
- Estimated price
- $70
- Schedules at
- Lewes Bus
- Phone
- +1 615-939-8887
- [email protected]
- Website
- New York to Tennessee Bus
Bus from Knoxville, TN to New York, NY
- Ave. Duration
- 12h
- Frequency
- Once daily
- Estimated price
- $95–110
- Website
- New York to Tennessee Bus
- Adult One-way
- $95–110
- Phone
- +1 540 982 2222
- [email protected]
- Website
- Valley Metro Roanoke
Bus from Exit 118 - Park and Ride to Roanoke Campbell Court
- Ave. Duration
- 48 min
- Frequency
- Every 3 hours
- Estimated price
- $1–4
- Website
- Valley Metro Roanoke
- Ave. Duration
- 59 min
- Estimated price
- $95–170
Taxi, Etc
- Phone
- +1-443-736-3241
- Website
- taxietc.weebly.com
Reliable Taxi
- Phone
- +1-423-426-6003
Reliable Taxi
- Phone
- +1-423-426-6003
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