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How to get fromKnoxville to Louisvilleby plane, bus (Greyhound, Amtrak, Flixbus), or car

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There are 4 ways to get from Knoxville to Louisville by plane, bus (Greyhound, Amtrak, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Louisville International Airport (SDF)plane plane TYS - SDF
    4h 14m
    $153–670

  2. Drive 234.8 mi

    cheapest
    1. Drive from Knoxville to Louisvillecar car 234.8 mi
    4h 31m
    $43–62

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Louisville Bus Stationbus bus Greyhound US0105 / ...
    7h 28m
    $159–224

  4. Fly to Blue Grass Airport, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Blue Grass Airport (LEX)plane plane TYS - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 13m
    $240–1,086

Mcghee Tyson Airport (TYS) to Louisville International Airport (SDF) flights

Calendar94Weekly Planes
Duration4h 22mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Louisville.ExpandLaunch map view
  • Distance: 209.1 mi
  • Duration: 4h 14m

What companies run services between Knoxville, TN, USA and Louisville, KY, USA?

Southwest Airlines, Delta, and three other airlines fly from Mcghee Tyson Airport (TYS) to Louisville International Airport (SDF) hourly. Alternatively, you can take a vehicle from Knoxville to Louisville Bus Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville Bus Station in around 7h 28m.

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