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How to get fromKnoxville to Madisonby plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Knoxville to Madison by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Dane County Regional Airport-Truax Field

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Dane County Regional Airport-Truax Field (MSN)plane plane TYS - MSN
    5h 8m
    $169–719

  2. Drive  673.7 mi

    cheapest
    1. Drive from Knoxville to Madisoncar car 673.7 mi
    11h 42m
    $123–178

  3. Bus, train

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Chicago Bus Stationbus bus
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    4. Take the bus from Milwaukee, WI - Amtrak to Madison, WI-Lake St.bus bus
    20h 8m
    $244–379

  4. Fly to General Mitchell International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to General Mitchell International Airport (MKE)plane plane TYS - MKE
    2. Take the bus from Mitchell Airport to Madison, WI-Lake St.bus bus
    6h 57m
    $177–702

  5. Fly to Chicago O'Hare International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane plane TYS - ORD
    2. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus
    6h 19m
    $136–502

  6. Bus

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Tornado Bus Co - West Memphisbus bus
    3. Take the bus from Tornado Bus Co - West Memphis to Water & Chicago - Circle Kbus bus
    4. Take the bus from Milwaukee, WI - Amtrak to Madison, WI-Lake St.bus bus
    23h 48m
    $306–410

  7. Bus via Chicago

    1. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    2. Take the bus from Memphis Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    25h 8m
    $250–381

Mcghee Tyson Airport (TYS) to Dane County Regional Airport-Truax Field (MSN) flights

Calendar146Weekly Planes
Duration5h 1mAverage Duration
Ticket$117Cheapest Price
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Comparing Your Travel Options

Map of how to get from Knoxville to Madison.ExpandLaunch map view
  • Distance: 600.9 mi
  • Duration: 5h 8m

What companies run services between Knoxville, TN, USA and Madison, WI, USA?

United Airlines, American Airlines, and Delta fly from Mcghee Tyson Airport (TYS) to Dane County Regional Airport-Truax Field (MSN) hourly. Alternatively, you can take a vehicle from Knoxville to Madison, WI-Lake St. via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, Tornado Bus Co - West Memphis, Water & Chicago - Circle K, and Milwaukee, WI - Amtrak in around 23h 48m.

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