Rome2Rio

How to get fromKnoxville to Manchesterby plane, bus, train, car, shuttle, or taxi

Find Transport to Manchester

See all options

There are 7 ways to get from Knoxville to Manchester by plane, bus, train, car, shuttle, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Mcghee Tyson Airport to Manchester Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Manchester Airport (MHT)plane plane TYS - MHT
    5h 37m
    $178–719

  2. Drive to Asheville Regional Airport, fly to Boston Logan Airport, bus

    cheapest
    1. Drive from Knoxville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Boston Logan Airport (BOS)plane plane AVL - BOS
    3. Take the bus from Boston to Manchester(Veterans Memorial Park)bus bus
    6h 57m
    $106–441

  3. Bus, train

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Bostontrain train
    3. Take the bus from Boston to Manchester(Veterans Memorial Park)bus bus
    19h 15m
    $218–339

  4. Drive, shuttle, taxi, bus, train

    1. Drive from Knoxville to Hot Springscar car
    2. Take a shuttle bus from Hot Springs to Black Bear Resortshuttle bus
    3. Take the taxi from Black Bear Resort to Bristol Exit 5 Park & Ride Lottaxi taxi
    4. Take the bus from Bristol Exit 5 Park & Ride Lot to Christiansburgbus bus
    5. Take the bus from Exit 118 - Park and Ride to Roanoke Campbell Courtbus bus Swb
    6. Take the train from Roanoke to Bostontrain train
    7. Take the bus from Boston to Manchester(Veterans Memorial Park)bus bus
    29h 48m
    $488–775

  5. Drive 933.7 mi

    1. Drive from Knoxville to Manchestercar car 933.7 mi
    16h 37m
    $171–247

  6. Fly Mcghee Tyson Airport to Boston Logan Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Boston Logan Airport (BOS)plane plane TYS - BOS
    2. Take the bus from Boston to Manchester(Veterans Memorial Park)bus bus
    5h 12m
    $176–686

  7. Drive, shuttle, taxi, bus, train via Washington

    1. Drive from Chilhowee at Holston to Hot Springscar car
    2. Take a shuttle bus from Hot Springs to Black Bear Resortshuttle bus
    3. Take the taxi from Black Bear Resort to Bristol Exit 5 Park & Ride Lottaxi taxi
    4. Take the bus from Bristol Exit 5 Park & Ride Lot to Washington Union Stationbus bus
    5. Take the train from Washington Union Station to Bostontrain train
    6. Take the bus from Boston to Manchester(Veterans Memorial Park)bus bus
    23h 26m
    $443–657

Mcghee Tyson Airport (TYS) to Manchester Airport (MHT) flights

Calendar82Weekly Planes
Duration5h 33mAverage Duration
Ticket$126Cheapest Price
See schedules

Questions & Answers

Map of how to get from Knoxville to Manchester.ExpandLaunch map view
  • Distance: 848 mi
  • Duration: 5h 37m

What companies run services between Knoxville, TN, USA and Manchester, NH, USA?

Southwest Airlines, United Airlines, and American Airlines fly from Mcghee Tyson Airport (TYS) to Manchester Airport (MHT) every 2 hours.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound