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How to get fromKnoxville to Mayo Clinicby plane, bus, train, or car

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There are 5 ways to get from Knoxville to Mayo Clinic by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Rochester (RST)plane plane TYS - RST
    6h 45m
    $168–707

  2. Drive 873.6 mi

    cheapest
    1. Drive from Knoxville to Mayo Cliniccar car 873.6 mi
    14h 56m
    $160–231

  3. Bus, train

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Chicago Bus Stationbus bus
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    26h 8m
    $361–619

  4. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Minneapolis–Saint Paul International Airport (MSP)plane plane TYS - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 40m
    $249–869

  5. Bus

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Tornado Bus Co - West Memphisbus bus
    3. Take the bus from Tornado Bus Co - West Memphis to Water & Chicago - Circle Kbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    28h 1m
    $349–650

Mcghee Tyson Airport (TYS) to Rochester (RST) flights

Calendar55Weekly Planes
Duration6h 53mAverage Duration
Ticket$113Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Mayo Clinic.ExpandLaunch map view
  • Distance: 739.7 mi
  • Duration: 6h 45m

What companies run services between Knoxville, TN, USA and Mayo Clinic, MN, USA?

Delta and American Airlines fly from Mcghee Tyson Airport (TYS) to Rochester (RST) every 4 hours. Alternatively, you can take a vehicle from Knoxville to Mayo Clinic via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, Tornado Bus Co - West Memphis, Water & Chicago - Circle K, Milwaukee, and Rochester in around 28h 1m.

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