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How to get fromKnoxville to Mesaby plane, bus, train, or car

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There are 5 ways to get from Knoxville to Mesa by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Phoenix (PHX)plane plane TYS - PHX
    5h 2m
    $239–869

  2. Bus

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Tornado Bus Co - West Memphisbus bus
    3. Take the bus from Tornado Bus Co - West Memphis to Tornado Bus Co - San Antoniobus bus
    4. Take the bus from San Antonio, TX - Tornado Bus Co to El Paso, TX - Tornado Bus Cobus bus
    5. Take the bus from El Paso to Phoenixbus bus
    41h 20m
    $456–897

  3. Bus, train via Galesburg

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Galesburgbus bus
    4. Take the train from Galesburg Amtrak Station to Flagstafftrain train
    5. Take the bus from Flagstaff Train Station to Tempebus bus
    2d 7h
    $796–1,533

  4. Drive 1,796.5 mi

    1. Drive from Knoxville to Mesacar car 1,796.5 mi
    28h 37m
    $328–474

  5. Bus, train

    1. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    2. Take the bus from Memphis Bus Station to Jacksonbus bus
    3. Take the train from Jackson to New Orleans Union Passenger Terminaltrain train
    4. Take the train from New Orleans Union Passenger Terminal to Tucson Amtrak Stationtrain train
    5. Take the bus from Tucson Downtown to Tempebus bus
    2d 9h
    $763–1,446

Mcghee Tyson Airport (TYS) to Phoenix (PHX) flights

Calendar50Weekly Planes
Duration6h 9mAverage Duration
Ticket$187Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Mesa.ExpandLaunch map view
  • Distance: 1,620.5 mi
  • Duration: 5h 2m

What companies run services between Knoxville, TN, USA and Mesa, AZ, USA?

Allegiant Air, Southwest Airlines, and American Airlines fly from Mcghee Tyson Airport (TYS) to Phoenix (PHX) every 4 hours. Alternatively, you can take a vehicle from Knoxville to Mesa Dr/Main St via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, Tornado Bus Co - West Memphis, San Antonio, TX - Tornado Bus Co, El Paso, TX - Tornado Bus Co, El Paso, Phoenix, and 24th St/Jefferson in around 41h 20m.

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