Rome2Rio

How to get fromKnoxville to Middlesboroby car or bus

Find Transport to Middlesboro

See all options

Comparing Your Travel Options

What companies run services between Knoxville, TN, USA and Middlesboro, KY, USA?

You can drive from Knoxville to Middlesboro in around 1h 28m.

Operators

Want to know more about travelling around the world?

Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including Italian Lakes: Getting around by train, The beginner’s guide to the 2018 World Nomad Games, and Need to know: Jadrolinija - to help you get the most out of your next trip.