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How to get fromKnoxville to Milwaukeeby plane, bus, train, or car

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There are 6 ways to get from Knoxville to Milwaukee by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to General Mitchell International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to General Mitchell International Airport (MKE)plane plane TYS - MKE
    4h 54m
    $170–720

  2. Drive  614.9 mi

    cheapest
    1. Drive from Knoxville to Milwaukeecar car 614.9 mi
    10h 55m
    $113–163

  3. Bus, train

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Central 5Th Ave - Bay 11 to Clarksville Exit 11 Park And Ridebus bus 94
    3. Take the bus from Clarksville Park & Ride to Carbondale Intermodal Stationbus bus
    4. Take the train from Carbondale to Chicago Union Stationtrain train
    5. Take the train from Chicago Union Station to Milwaukeetrain train
    18h 44m
    $372–554

  4. Fly to Chicago O'Hare International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane plane TYS - ORD
    2. Take the bus from Chicago to Milwaukee Intermodal Stationbus bus
    4h 45m
    $126–432

  5. Fly to Chicago Midway International Airport, train

    1. Fly from Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW)plane plane TYS - MDW
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    5h 10m
    $174–567

  6. Bus

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Tornado Bus Co - West Memphisbus bus
    3. Take the bus from Tornado Bus Co - West Memphis to Water & Chicago - Circle Kbus bus
    21h
    $287–370

Mcghee Tyson Airport (TYS) to General Mitchell International Airport (MKE) flights

Calendar112Weekly Planes
Duration5h 1mAverage Duration
Ticket$111Cheapest Price
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Comparing Your Travel Options

Map of how to get from Knoxville to Milwaukee.ExpandLaunch map view
  • Distance: 554.9 mi
  • Duration: 4h 54m

What companies run services between Knoxville, TN, USA and Milwaukee, WI, USA?

Delta, United Airlines, and two other airlines fly from Mcghee Tyson Airport (TYS) to General Mitchell International Airport (MKE) hourly. Alternatively, you can take a vehicle from Knoxville to Water & Chicago - Circle K via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, and Tornado Bus Co - West Memphis in around 21h.

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