Rome2Rio

How to get fromKnoxville to Missouriby plane, bus (Greyhound, Flixbus), car, bus, or train

Find Transport to Missouri

See all options

There are 6 ways to get from Knoxville to Missouri by plane, bus (Greyhound, Flixbus), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Lambert–St. Louis International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL)plane plane TYS - STL
    4h 40m
    $145–620

  2. Drive  727.7 mi

    cheapest
    1. Drive from Knoxville to Kansas Citycar car 727.7 mi
    12h 8m
    $133–192

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus
    16h 34m
    $213–314

  4. Fly to Springfield-Branson National Airport

    1. Fly from Mcghee Tyson Airport (TYS) to Springfield-Branson National Airport (SGF)plane plane TYS - SGF
    5h 1m
    $158–557

  5. Fly to Kansas City

    1. Fly from Mcghee Tyson Airport (TYS) to Kansas City (MCI)plane plane TYS - MCI
    5h 32m
    $177–767

  6. Bus, train

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Central 5Th Ave - Bay 11 to Clarksville Exit 11 Park And Ridebus bus 94
    3. Take the bus from Clarksville Park & Ride to St Louis Bus Stationbus bus
    4. Take the train from St. Louis to Kansas Citytrain train
    19h 7m
    $243–399

Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) flights

Calendar132Weekly Planes
Duration4h 50mAverage Duration
Ticket$89Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Knoxville to Missouri.ExpandLaunch map view
  • Distance: 431.1 mi
  • Duration: 4h 40m

What companies run services between Knoxville, TN, USA and Missouri, USA?

Delta, Southwest Airlines, and two other airlines fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a vehicle from Knoxville to Kansas City Bus Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and St Louis Bus Station in around 16h 34m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There