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How to get fromKnoxville to Missouriby plane, bus (Greyhound, Flixbus), car, bus, or train

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There are 6 ways to get from Knoxville to Missouri by plane, bus (Greyhound, Flixbus), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Lambert–St. Louis International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL)plane plane TYS - STL
    4h 35m
    $150–670

  2. Drive  727.7 mi

    cheapest
    1. Drive from Knoxville to Kansas Citycar car 727.7 mi
    12h 8m
    $133–192

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus
    16h 34m
    $218–314

  4. Fly to Springfield-Branson National Airport

    1. Fly from Mcghee Tyson Airport (TYS) to Springfield-Branson National Airport (SGF)plane plane TYS - SGF
    4h 27m
    $163–587

  5. Fly to Kansas City

    1. Fly from Mcghee Tyson Airport (TYS) to Kansas City (MCI)plane plane TYS - MCI
    5h 43m
    $177–767

  6. Bus, train

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Central 5Th Ave - Bay 11 to Clarksville Exit 11 Park And Ridebus bus 94
    3. Take the bus from Clarksville Park & Ride to St Louis Bus Stationbus bus
    4. Take the train from St. Louis to Kansas Citytrain train
    19h 7m
    $248–439

Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) flights

Calendar135Weekly Planes
Duration5h 19mAverage Duration
Ticket$92Cheapest Price
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Comparing Your Travel Options

Map of how to get from Knoxville to Missouri.ExpandLaunch map view
  • Distance: 431.1 mi
  • Duration: 4h 35m

What companies run services between Knoxville, TN, USA and Missouri, USA?

Southwest Airlines, Delta, and two other airlines fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a vehicle from Knoxville to Kansas City Bus Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and St Louis Bus Station in around 16h 34m.

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