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How to get fromKnoxville to Mobileby plane, bus (Greyhound), car, or bus

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There are 5 ways to get from Knoxville to Mobile by plane, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mobile Regional Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Mobile Regional Airport (MOB)plane plane TYS - MOB
    3h 53m
    $152–517

  2. Drive  499.6 mi

    cheapest
    1. Drive from Knoxville to Mobilecar car 499.6 mi
    8h 39m
    $92–132

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Montgomery Intermodal Centerbus bus
    3. Take the bus from Montgomery Intermodal Center to Mobile Bus Stationbus bus
    14h 54m
    $199–284

  4. Fly to Destin–Fort Walton Beach Airport, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Destin–Fort Walton Beach Airport (VPS)plane plane TYS - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Mobilecar car
    3h 46m
    $136–485

  5. Fly to Gulfport-Biloxi Regional Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Gulfport-Biloxi Regional Airport (GPT)plane plane TYS - GPT
    2. Take the bus from Gulfport to Mobilebus bus
    6h 13m
    $204–698

Mcghee Tyson Airport (TYS) to Mobile Regional Airport (MOB) flights

Calendar87Weekly Planes
Duration4h 52mAverage Duration
Ticket$68Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Mobile.ExpandLaunch map view
  • Distance: 456.6 mi
  • Duration: 3h 53m

What companies run services between Knoxville, TN, USA and Mobile, AL, USA?

Delta, American Airlines, and United Airlines fly from Mcghee Tyson Airport (TYS) to Mobile Regional Airport (MOB) every 2 hours. Alternatively, you can take a vehicle from Knoxville to Govt EB at Franklin St via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, Montgomery Intermodal Center, Mobile Bus Station, and Govt EB at Greyhound Bus Station in around 14h 54m.

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