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How to get fromKnoxville to Murphysboroby bus (Flixbus), car, plane, bus, or taxi

Find Transport to Murphysboro

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There are 6 ways to get from Knoxville to Murphysboro by bus (Flixbus), car, plane, bus, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus FlixBus N2521
    8h 55m
    $182–247

  2. Drive 384.2 mi

    cheapest
    1. Drive from Knoxville to Murphysborocar car 384.2 mi
    6h 31m
    $71–102

  3. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL)plane plane TYS - STL
    2. Take the bus from St. Louis to Carbondalebus bus
    7h 21m
    $204–843

  4. Fly to Nashville, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Nashville (BNA)plane plane TYS - BNA
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    6h 57m
    $163–567

  5. Fly to Evansville, bus, taxi

    1. Fly from Mcghee Tyson Airport (TYS) to Evansville (EVV)plane plane TYS - EVV
    2. Take the bus from Evansville Bus Station to Mount Vernonbus bus
    3. Take the taxi from Mount Vernon to Murphysborotaxi taxi
    7h 42m
    $312–787

  6. Fly to Williamson County Regional Airport

    1. Fly from Mcghee Tyson Airport (TYS) to Williamson County Regional Airport (MWA)plane plane TYS - MWA
    6h 49m
    $222–727

Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) flights

Calendar125Weekly Planes
Duration4h 54mAverage Duration
Ticket$117Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Murphysboro.ExpandLaunch map view
  • Distance: 403.8 mi
  • Duration: 8h 55m

What companies run services between Knoxville, TN, USA and Murphysboro, IL, USA?

You can take a vehicle from Knoxville to Murphysboro via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and Carbondale Intermodal Station in around 8h 55m. Alternatively, American Airlines, Corporate Flight Management Inc, and two other airlines fly from Mcghee Tyson Airport (TYS) to Williamson County Regional Airport (MWA) every 4 hours.

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