There are 4 ways to get from Knoxville to Murphysboro by bus (Flixbus), car, plane, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Knoxville to Nashvillebus Nyc
- Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus FlixBus N2521
9h$182–242Drive 384.2 mi
cheapest- Drive from Knoxville to Murphysborocar 384.2 mi
6h 31m$71–102Fly to Williamson County Regional Airport
- Fly from Mcghee Tyson Airport (TYS) to Williamson County Regional Airport (MWA)plane TYS - MWA
5h 41m$197–677Fly to Lambert–St. Louis International Airport, bus
- Fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL)plane TYS - STL
- Take the bus from St. Louis to Carbondalebus
7h 51m$183–728
Mcghee Tyson Airport (TYS) to Williamson County Regional Airport (MWA) flights
Comparing Your Travel Options
The cheapest way to get from Knoxville to Murphysboro is to drive which costs $70 - $110 and takes 6h 31m.
The fastest way to get from Knoxville to Murphysboro is to fly which takes 5h 41m and costs $190 - $700.
No, there is no direct bus from Knoxville to Murphysboro station. However, there are services departing from Knoxville and arriving at Carbondale Intermodal Station via Charlotte Pike & Lellyett St Eb, Central 4Th Ave - Bay 13 and Nashville Bus Station. The journey, including transfers, takes approximately 9h.
The distance between Knoxville and Murphysboro is 407 miles. The road distance is 386.5 miles.
The best way to get from Knoxville to Murphysboro without a car is to bus which takes 9h and costs $180 - $250.
It takes approximately 9h to get from Knoxville to Murphysboro, including transfers.
Knoxville to Murphysboro bus services, operated by Wanda Coach, depart from Knoxville station.
The best way to get from Knoxville to Murphysboro is to bus which takes 9h and costs $180 - $250. Alternatively, you can fly, which costs $190 - $700 and takes 5h 41m.
Knoxville to Murphysboro bus services, operated by Wanda Coach, arrive at Nashville station.
Murphysboro is 1h behind Knoxville. It is currently 10:06 AM in Knoxville and 9:06 AM in Murphysboro.
What companies run services between Knoxville, TN, USA and Murphysboro, IL, USA?
You can take a vehicle from Knoxville to Murphysboro via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and Carbondale Intermodal Station in around 9h. Alternatively, American Airlines and United Airlines fly from Mcghee Tyson Airport (TYS) to Williamson County Regional Airport (MWA) 4 times a day.
- Website
- aa.com
Flights from Mcghee Tyson Airport to Williamson County Regional Airport via Chicago O'Hare
- Ave. Duration
- 5h 54m
- When
- Every day
- Estimated price
- $95–550
Flights from Mcghee Tyson Airport to Williamson County Regional Airport via Charlotte, Chicago O'Hare
- Ave. Duration
- 8h 50m
- When
- Every day
- Estimated price
- $120–600
Flights from Mcghee Tyson Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 5h 45m
- When
- Every day
- Estimated price
- $120–700
Flights from Mcghee Tyson Airport to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 5h 50m
- When
- Every day
- Estimated price
- $120–700
- Phone
- +1 646-630-7186
- [email protected]
- Website
- Wanda Coach
Bus from Knoxville to Nashville
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $40–60
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $40–60
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Booking & Getting There
Yes, the driving distance between Knoxville to Murphysboro is 386 miles. It takes approximately 6h 31m to drive from Knoxville to Murphysboro.
There are 35+ hotels available in Murphysboro.