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How to get fromKnoxville to New Orleansby plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 5 ways to get from Knoxville to New Orleans by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louis Armstrong New Orleans International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Louis Armstrong New Orleans International Airport (MSY)plane plane TYS - MSY
    4h 56m
    $178–720

  2. Drive 598.4 mi

    cheapest
    1. Drive from Knoxville to New Orleanscar car 598.4 mi
    9h 48m
    $110–158

  3. Bus, train

    1. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    2. Take the bus from Memphis Bus Station to Jacksonbus bus
    3. Take the train from Jackson to New Orleans Union Passenger Terminaltrain train
    17h 1m
    $259–425

  4. Fly to Gulfport-Biloxi Regional Airport, train

    1. Fly from Mcghee Tyson Airport (TYS) to Gulfport-Biloxi Regional Airport (GPT)plane plane TYS - GPT
    2. Take the train from Gulfport, MS to New Orleans, LA - Union Passenger Terminaltrain train
    6h 35m
    $195–733

  5. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to New Orleans Bus Stationbus bus
    19h 39m
    $238–384

Mcghee Tyson Airport (TYS) to Louis Armstrong New Orleans International Airport (MSY) flights

Calendar48Weekly Planes
Duration4h 31mAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to New Orleans.ExpandLaunch map view
  • Distance: 566.7 mi
  • Duration: 4h 56m

What companies run services between Knoxville, TN, USA and New Orleans, LA, USA?

Southwest Airlines, Delta, and American Airlines fly from Mcghee Tyson Airport (TYS) to Louis Armstrong New Orleans International Airport (MSY) every 4 hours. Alternatively, you can take a vehicle from Knoxville to New Orleans Bus Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and Atlanta Bus Station in around 19h 39m.

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