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How to get fromKnoxville to Niagara Fallsby plane, bus, train, car, or bus (Greyhound)

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There are 8 ways to get from Knoxville to Niagara Falls by plane, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport, bus

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF)plane plane TYS - BUF
    2. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    5h 42m
    $172–725

  2. Drive  702.7 mi

    cheapest
    1. Drive from Knoxville to Niagara Fallscar car 702.7 mi
    12h
    $129–186

  3. Bus, train

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Niagara Falls Amtrak Stationtrain train Empire Service / ...
    22h 45m
    $390–563

  4. Fly to Toronto Pearson International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Toronto Pearson International Airport (YYZ)plane plane TYS - YYZ
    2. Take the bus from Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floor to Bus Terminalbus bus
    6h 53m
    $131–482

  5. Fly to Toronto Island Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Toronto Island Airport (YTZ)plane plane TYS - YTZ
    2. Take the bus from Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floor to Bus Terminalbus bus
    7h 42m
    $135–503

  6. Bus via Cleveland

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Indianapolisbus bus
    3. Take the bus from Indianapolis to Toledobus bus
    4. Take the bus from Toledo to Clevelandbus bus
    5. Take the bus from Cleveland to Buffalobus bus
    28h 15m
    $302–488

  7. Bus, train via Speedway

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Indianapolisbus bus
    3. Take the bus from Indianapolis to Toledobus bus
    4. Take the train from Toledo to Buffalo Depew Stationtrain train
    5. Take the train from Buffalo Depew Station to Niagara Falls Amtrak Stationtrain train
    28h 19m
    $440–781

  8. Bus

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Columbusbus bus
    4. Take the bus from Columbus to Buffalobus bus
    30h 45m
    $317–448

Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF) flights

Calendar73Weekly Planes
Duration4h 58mAverage Duration
Ticket$115Cheapest Price
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Comparing Your Travel Options

Map of how to get from Knoxville to Niagara Falls.ExpandLaunch map view
  • Distance: 610.3 mi
  • Duration: 5h 42m

What companies run services between Knoxville, TN, USA and Niagara Falls, NY, USA?

You can take a vehicle from Knoxville to Main Street & Pine Avenue via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, Indianapolis, Indianapolis, Toledo, Cleveland, and Ellicott Street & MTC Static in around 28h 15m.

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Train operators
Bus operators

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