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How to get fromKnoxville to Notre Dameby plane, bus (Greyhound, Amtrak), car, train, or bus

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There are 7 ways to get from Knoxville to Notre Dame by plane, bus (Greyhound, Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to South Bend

    best
    1. Fly from Mcghee Tyson Airport (TYS) to South Bend (SBN)plane plane TYS - SBN
    4h 37m
    $157–572

  2. Drive  485.5 mi

    cheapest
    1. Drive from Knoxville to Notre Damecar car 485.5 mi
    8h 44m
    $89–128

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to South Street Station - South Bendbus bus
    15h 3m
    $231–390

  4. Fly to Kalamazoo-Battle Creek International Airport, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Kalamazoo-Battle Creek International Airport (AZO)plane plane TYS - AZO
    2. Drive from Kalamazoo-Airport-AZO to Notre Damecar car
    5h 22m
    $148–564

  5. Fly to Chicago Midway International Airport, train

    1. Fly from Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW)plane plane TYS - MDW
    2. Take the train from Van Buren St. to South Bend Airporttrain train
    5h 33m
    $168–563

  6. Fly to Chicago O'Hare International Airport, train

    1. Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane plane TYS - ORD
    2. Take the train from Van Buren St. to South Bend Airporttrain train
    6h 6m
    $148–463

  7. Bus, train

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Gary Bus Stationbus bus
    3. Take the train from Gary to South Bend Airporttrain train
    17h 13m
    $219–286

Mcghee Tyson Airport (TYS) to South Bend (SBN) flights

Calendar105Weekly Planes
Duration5h 19mAverage Duration
Ticket$84Cheapest Price
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Comparing Your Travel Options

Map of how to get from Knoxville to Notre Dame.ExpandLaunch map view
  • Distance: 444.2 mi
  • Duration: 4h 37m

What companies run services between Knoxville, TN, USA and Notre Dame, IN, USA?

United Airlines, American Airlines, and two other airlines fly from Mcghee Tyson Airport (TYS) to South Bend (SBN) hourly. Alternatively, you can take a vehicle from Knoxville to Notre Dame via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, Indianapolis Union Station, and South Street Station - South Bend in around 15h 3m.

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