Rome2Rio

How to get fromKnoxville to O'Fallonby plane, train, bus (Greyhound, Flixbus), or car

Find Transport to O'Fallon

See all options

There are 4 ways to get from Knoxville to O'Fallon by plane, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Lambert–St. Louis International Airport, train

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL)plane plane TYS - STL
    2. Take the train from LAMBERT AIRPORT TERMINAL #1 station to SHILOH-SCOTT stationtrain train
    5h 33m
    $171–771

  2. Drive 465.1 mi

    cheapest
    1. Drive from Knoxville to O'Falloncar car 465.1 mi
    7h 41m
    $85–123

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus Greyhound US0186 / ...
    13h 12m
    $182–268

  4. Fly to Midamerica St. Louis Airport

    1. Fly from Mcghee Tyson Airport (TYS) to Midamerica St. Louis Airport (BLV)plane plane TYS - BLV
    7h 26m
    $253–848

Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) flights

Calendar124Weekly Planes
Duration4h 56mAverage Duration
Ticket$116Cheapest Price
See schedules

Questions & Answers

Map of how to get from Knoxville to O'Fallon.ExpandLaunch map view
  • Distance: 460.6 mi
  • Duration: 5h 33m

What companies run services between Knoxville, TN, USA and O'Fallon, IL, USA?

You can take a vehicle from Knoxville to State @ Lincoln Eb via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, St Louis Bus Station, CIVIC CENTER station, FAIRVIEW HEIGHTS station, and Fairview Heights Transit Center in around 13h 12m. Alternatively, Allegiant Air flies from Mcghee Tyson Airport (TYS) to Midamerica St. Louis Airport (BLV) 4 times a week.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers