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How to get fromKnoxville to Ohioby plane, bus (Greyhound), car, or bus

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There are 7 ways to get from Knoxville to Ohio by plane, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Cleveland-Hopkins International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Cleveland-Hopkins International Airport (CLE)plane plane TYS - CLE
    4h 9m
    $190–770

  2. Drive 357.1 mi

    cheapest
    1. Drive from Knoxville to Columbuscar car 357.1 mi
    6h 2m
    $66–95

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Columbusbus bus Greyhound US0105
    14h 9m
    $198–299

  4. Fly to John Glenn Columbus International Airport

    1. Fly from Mcghee Tyson Airport (TYS) to John Glenn Columbus International Airport (CMH)plane plane TYS - CMH
    5h
    $179–820

  5. Fly to Covington

    1. Fly from Mcghee Tyson Airport (TYS) to Covington (CVG)plane plane TYS - CVG
    5h 9m
    $170–772

  6. Fly to Dayton

    1. Fly from Mcghee Tyson Airport (TYS) to Dayton (DAY)plane plane TYS - DAY
    5h 27m
    $299–1,469

  7. Fly to Detroit, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Detroit (DTW)plane plane TYS - DTW
    2. Take the bus from Dearborn to Toledobus bus
    5h 25m
    $190–763

Mcghee Tyson Airport (TYS) to Cleveland-Hopkins International Airport (CLE) flights

Calendar114Weekly Planes
Duration4h 26mAverage Duration
Ticket$129Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Ohio.ExpandLaunch map view
  • Distance: 428.1 mi
  • Duration: 4h 9m

What companies run services between Knoxville, TN, USA and Ohio, USA?

Southwest Airlines, Delta, and two other airlines fly from Mcghee Tyson Airport (TYS) to Cleveland-Hopkins International Airport (CLE) hourly. Alternatively, you can take a vehicle from Knoxville to Columbus via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville Bus Station in around 14h 9m.

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