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How to get fromKnoxville to Orangeburgby plane, taxi, car, shuttle, or bus

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There are 5 ways to get from Knoxville to Orangeburg by plane, taxi, car, shuttle, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Columbia, taxi

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Columbia (CAE)plane plane TYS - CAE
    2. Take the taxi from Columbia-Airport-CAE to Orangeburgtaxi taxi
    4h 3m
    $337–1,317

  2. Drive 300.6 mi

    cheapest
    1. Drive from Knoxville to Orangeburgcar car 300.6 mi
    5h 11m
    $55–80

  3. Drive, shuttle, bus

    1. Drive from Knoxville to Hot Springscar car
    2. Take a shuttle bus from Hot Springs to Black Bear Resortshuttle bus
    3. Take a shuttle bus from Black Bear Resort to Booneshuttle bus
    4. Take the bus from ASU Peacock Hall Boone to Charlotte Airportbus bus
    5. Take the bus from Charlotte Bus Station to Orangeburgbus bus
    13h 58m
    $362–417

  4. Fly to Augusta Regional Airport At Bush Field, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Augusta Regional Airport At Bush Field (AGS)plane plane TYS - AGS
    2. Drive from Augusta Regional Airport At Bush Field (AGS) to Orangeburgcar car
    5h 12m
    $136–528

  5. Drive, shuttle, taxi, bus

    1. Drive from Chilhowee at Holston to Hot Springscar car
    2. Take a shuttle bus from Hot Springs to Black Bear Resortshuttle bus
    3. Take the taxi from Black Bear Resort to ASU Peacock Hall Boonetaxi taxi
    4. Take the bus from ASU Peacock Hall Boone to Charlotte Airportbus bus
    5. Take the bus from Charlotte Bus Station to Orangeburgbus bus
    14h 20m
    $397–482

Mcghee Tyson Airport (TYS) to Columbia (CAE) flights

Calendar142Weekly Planes
Duration4h 25mAverage Duration
Ticket$167Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Orangeburg.ExpandLaunch map view
  • Distance: 258.8 mi
  • Duration: 4h 3m

What companies run services between Knoxville, TN, USA and Orangeburg, SC, USA?

There is no direct connection from Knoxville to Orangeburg. However, you can take the taxi to Mcghee Tyson Airport (TYS) airport, fly to Columbia (CAE), then take the taxi to Orangeburg. Alternatively, you can take a vehicle from Knoxville to Orangeburg via Hot Springs, Black Bear Resort, Boone, ASU Peacock Hall Boone, Charlotte Airport, Charlotte Douglas Airport, Transit Center- Bay V, Transit Center- Bay E, 4th St & Graham St, Charlotte Bus Station, and Orangeburg in around 13h 58m.

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