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How to get fromKnoxville to Panama City Beachby plane, bus (Greyhound), or car

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There are 6 ways to get from Knoxville to Panama City Beach by plane, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Mcghee Tyson Airport to Northwest Florida Beaches International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Northwest Florida Beaches International Airport (ECP)plane plane TYS - ECP
    3h 43m
    $182–602

  2. Drive 478.5 mi

    cheapest
    1. Drive from Knoxville to Panama City Beachcar car 478.5 mi
    9h 15m
    $88–127

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    17h 34m
    $227–351

  4. Fly Mcghee Tyson Airport to Destin–Fort Walton Beach Airport, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Destin–Fort Walton Beach Airport (VPS)plane plane TYS - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    3h 1m
    $142–553

  5. Fly Mcghee Tyson Airport to Dothan Regional Airport, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Dothan Regional Airport (DHN)plane plane TYS - DHN
    2. Drive from Dothan Regional Airport (DHN) to Panama City Beachcar car
    5h 36m
    $144–543

  6. Drive to Asheville Regional Airport, fly to Northwest Florida Beaches International Airport

    1. Drive from Knoxville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Northwest Florida Beaches International Airport (ECP)plane plane AVL - ECP
    6h 4m
    $127–427

Mcghee Tyson Airport (TYS) to Northwest Florida Beaches International Airport (ECP) flights

Calendar55Weekly Planes
Duration4h 15mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Panama City Beach.ExpandLaunch map view
  • Distance: 422 mi
  • Duration: 3h 43m

What companies run services between Knoxville, TN, USA and Panama City Beach, FL, USA?

Delta, Southwest Airlines, and American Airlines fly from Mcghee Tyson Airport (TYS) to Northwest Florida Beaches International Airport (ECP) every 4 hours. Alternatively, you can take a vehicle from Knoxville to Panama City Beach via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, Tallahassee, and Panama City Beach Bus Station in around 17h 34m.

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