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How to get fromKnoxville to Pittsburghby plane, bus, train, car, or bus (Flixbus)

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There are 4 ways to get from Knoxville to Pittsburgh by plane, bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Pittsburgh International Airport (PIT)plane plane TYS - PIT
    5h 6m
    $157–667

  2. Drive 485.7 mi

    cheapest
    1. Drive from Knoxville to Pittsburghcar car 485.7 mi
    8h 22m
    $89–128

  3. Bus, train

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Pittsburgh Amtrak Stationtrain train Pennsylvanian
    22h 50m
    $280–453

  4. Bus

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the bus from New York City Chinatown to Pittsburgh Intermodal Stationbus bus FlixBus N2640
    25h 54m
    $168–234

Mcghee Tyson Airport (TYS) to Pittsburgh International Airport (PIT) flights

Calendar124Weekly Planes
Duration4h 18mAverage Duration
Ticket$105Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Pittsburgh.ExpandLaunch map view
  • Distance: 420 mi
  • Duration: 5h 6m

What companies run services between Knoxville, TN, USA and Pittsburgh, PA, USA?

Southwest Airlines, Delta, and two other airlines fly from Mcghee Tyson Airport (TYS) to Pittsburgh International Airport (PIT) hourly. Alternatively, you can take a bus from Knoxville Station Bay H to Pittsburgh Intermodal Station via Fountain City Superstop, Walmart, Knoxville, TN, and New York City Chinatown in around 25h 54m.

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