What is the cheapest way to get from Knoxville to Port Saint Lucie?

The cheapest way to get from Knoxville to Port Saint Lucie is to drive which costs $130 - $200 and takes 12h 34m.

What is the fastest way to get from Knoxville to Port Saint Lucie?

The fastest way to get from Knoxville to Port Saint Lucie is to fly and drive which takes 4h 24m and costs $170 - $600.

Is there a direct bus between Knoxville and Port Saint Lucie?

No, there is no direct bus from Knoxville to Port Saint Lucie. However, there are services departing from Knoxville and arriving at SW PSL Blvd & Cameo Blvd - East via Charlotte Pike & Lellyett St Eb, Central 4Th Ave - Bay 13, Nashville Bus Station, Atlanta Bus Station and SW Gatlin Blvd & SW Brescia St. The journey, including transfers, takes approximately 22h 17m.

How far is it from Knoxville to Port Saint Lucie?

The distance between Knoxville and Port Saint Lucie is 660 miles. The road distance is 755.3 miles.

How do I travel from Knoxville to Port Saint Lucie without a car?

The best way to get from Knoxville to Port Saint Lucie without a car is to bus which takes 22h 17m and costs $250 - $390.

How long does it take to get from Knoxville to Port Saint Lucie?

It takes approximately 4h 24m to get from Knoxville to Port Saint Lucie, including transfers.

Where do I catch the Knoxville to Port Saint Lucie bus from?

Knoxville to Port Saint Lucie bus services, operated by Wanda Coach, depart from Knoxville station.

Where does the Knoxville to Port Saint Lucie bus arrive?

Knoxville to Port Saint Lucie bus services, operated by Wanda Coach, arrive at Nashville station.

Can I drive from Knoxville to Port Saint Lucie?

Yes, the driving distance between Knoxville to Port Saint Lucie is 755 miles. It takes approximately 12h 34m to drive from Knoxville to Port Saint Lucie.

Where can I stay near Port Saint Lucie?

There are 524+ hotels available in Port Saint Lucie.

Knoxville to Port Saint Lucie - 6 ways to travel via plane, car, and bus

How to get fromKnoxville to Port Saint Lucie

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There are 6 ways to get from Knoxville to Port Saint Lucie by plane, car, bus (Greyhound, Flixbus), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly to Orlando Sanford, drive
best
1. Fly from Mcghee Tyson Airport (TYS) to Orlando Sanford (SFB)plane TYS - SFB
2. Drive from Orlando-Sanford-Airport-SFB to Port Saint Luciecar
4h 24m
$171–602
Drive 750.9 mi
cheapest
1. Drive from Knoxville to Port Saint Luciecar 750.9 mi
12h 34m
$137–198
Bus
1. Take the bus from Knoxville to Nashvillebus Nyc
2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus
3. Take the bus from Atlanta Bus Station to Port St Luciebus
22h 17m
$258–389
Fly to Fort Lauderdale–Hollywood International Airport, bus
1. Fly from Mcghee Tyson Airport (TYS) to Fort Lauderdale–Hollywood International Airport (FLL)plane TYS - FLL
2. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus
6h 1m
$197–712
Fly to Orlando, bus
1. Fly from Mcghee Tyson Airport (TYS) to Orlando (MCO)plane TYS - MCO
2. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus
6h 28m
$181–611
Fly to Miami International Airport, bus
1. Fly from Mcghee Tyson Airport (TYS) to Miami International Airport (MIA)plane TYS - MIA
2. Take the bus from Sheridan Tri-Rail Station to Fort Piercebus
6h 27m
$200–713

Mcghee Tyson Airport (TYS) to Orlando Sanford (SFB) flights

11Weekly Planes

1h 37mAverage Duration

$90Cheapest Price

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Questions & Answers

Map of how to get from Knoxville to Port Saint Lucie.

Launch map view

Distance: 655.7 mi
Duration: 4h 24m

What companies run services between Knoxville, TN, USA and Port Saint Lucie, FL, USA?

You can take a vehicle from Knoxville to SW PSL Blvd & Cameo Blvd - East via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, Atlanta Bus Station, and SW Gatlin Blvd & SW Brescia St in around 22h 17m.

Airlines

Bus operators

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How to get fromKnoxville to Port Saint Lucieby plane, car, bus (Greyhound, Flixbus), or bus

There are 6 ways to get from Knoxville to Port Saint Lucie by plane, car, bus (Greyhound, Flixbus), or bus

Fly to Orlando Sanford, drive

Drive 750.9 mi

Bus

Fly to Fort Lauderdale–Hollywood International Airport, bus

Fly to Orlando, bus

Fly to Miami International Airport, bus