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How to get fromKnoxville to Rochesterby plane, bus, train, car, or bus (Greyhound)

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There are 7 ways to get from Knoxville to Rochester by plane, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Rochester (ROC)plane plane TYS - ROC
    4h 19m
    $232–986

  2. Drive  746.5 mi

    cheapest
    1. Drive from Knoxville to Rochestercar car 746.5 mi
    12h 55m
    $137–197

  3. Bus, train

    1. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    2. Take the train from New York Penn Station to Rochestertrain train VIA Rail
    20h 34m
    $235–423

  4. Fly to Buffalo Niagara International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF)plane plane TYS - BUF
    2. Take the bus from Buffalo Niagara International Airport to Rochester Bus Stopbus bus
    6h 22m
    $186–733

  5. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Rochester Bus Stopbus bus
    23h 29m
    $263–434

  6. Bus, train via Jackson

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to El Mercadito Grocery - Clarksville, INbus bus
    3. Take the bus from Louisville, KY Bus Station to Cleveland Ohio Greyhound Stationbus bus
    4. Take the train from Cleveland Amtrak to Rochestertrain train
    26h 25m
    $326–522

  7. Bus, train via Toledo

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to El Mercadito Grocery - Clarksville, INbus bus
    3. Take the bus from Louisville Bus Station to Toledo Bus Stopbus bus
    4. Take the train from Toledo to Rochestertrain train
    27h 40m
    $358–594

Mcghee Tyson Airport (TYS) to Rochester (ROC) flights

Calendar87Weekly Planes
Duration4h 45mAverage Duration
Ticket$164Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Rochester.ExpandLaunch map view
  • Distance: 623.9 mi
  • Duration: 4h 19m

What companies run services between Knoxville, TN, USA and Rochester, NY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Mcghee Tyson Airport (TYS) to Rochester (ROC) every 2 hours. Alternatively, you can take a vehicle from Knoxville to Rochester Bus Stop via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and Cleveland Bus Station in around 23h 29m.

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