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How to get fromKnoxville to San Antonioby plane, bus, train, or car

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There are 5 ways to get from Knoxville to San Antonio by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to San Antonio International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to San Antonio International Airport (SAT)plane plane TYS - SAT
    5h 13m
    $239–969

  2. Drive 1,109.7 mi

    cheapest
    1. Drive from Knoxville to San Antoniocar car 1,109.7 mi
    17h 41m
    $203–293

  3. Bus

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Tornado Bus Co - West Memphisbus bus
    3. Take the bus from Tornado Bus Co - West Memphis to Tornado Bus Co - San Antoniobus bus
    24h 44m
    $301–582

  4. Bus, train

    1. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    2. Take the bus from Memphis Bus Station to Jacksonbus bus
    3. Take the train from Jackson to New Orleans Union Passenger Terminaltrain train
    4. Take the train from New Orleans Union Passenger Terminal to San Antonio Stationtrain train
    33h 6m
    $439–805

  5. Fly to Austin-Bergstrom International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Austin-Bergstrom International Airport (AUS)plane plane TYS - AUS
    2. Take the bus from Austin Eastside Bus Plaza to San Antonio Bus Stationbus bus
    5h 42m
    $240–944

Mcghee Tyson Airport (TYS) to San Antonio International Airport (SAT) flights

Calendar91Weekly Planes
Duration5h 16mAverage Duration
Ticket$183Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to San Antonio.ExpandLaunch map view
  • Distance: 967.2 mi
  • Duration: 5h 13m

What companies run services between Knoxville, TN, USA and San Antonio, TX, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Mcghee Tyson Airport (TYS) to San Antonio International Airport (SAT) hourly. Alternatively, you can take a vehicle from Knoxville to S. St. Mary's & Nueva via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, Tornado Bus Co - West Memphis, Tornado Bus Co - San Antonio, and I-35 S Access & Yarrow Blvd in around 24h 44m.

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