There are 6 ways to get from Knoxville to San Diego by plane, bus, train, bus (Greyhound, Amtrak), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Mcghee Tyson Airport
best- Fly from Mcghee Tyson Airport (TYS) to San Diego International Airport (SAN)plane TYS - SAN
6h 17m$297–1,067Drive to Asheville Regional Airport, fly
cheapest- Drive from Knoxville to Asheville-Airport-AVLcar
- Fly from Asheville Regional Airport (AVL) to San Diego International Airport (SAN)plane AVL - SAN
8h 28m$192–732Bus, train via Kansas City
- Take the bus from Knoxville to Memphis - Summer Avebus Nyc
- Take the bus from Memphis Bus Station to St Louis Bus Stationbus
- Take the train from St. Louis to Kansas Citytrain
- Take the train from Kansas City to Fullerton Amtrak Stationtrain
- Take the train from Fullerton Amtrak Station to San Diegotrain
2d 11h$879–1,775Bus
- Take the bus from Knoxville to Jacksonbus Nyc
- Take the bus from El Mezcal Grocery - Jackson, TN to Indianapolisbus
- Take the bus from Indianapolis Union Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Los Angeles Union Stationbus
- Take the bus from Los Angeles to San Diegobus
2d 17h$595–1,086Drive 2,155.6 mi
- Drive from Knoxville to San Diegocar 2,155.6 mi
34h 42m$394–569Bus, train
- Take the bus from Knoxville to Jacksonbus
- Take the bus from El Mezcal Grocery - Jackson, TN to Indianapolisbus
- Take the train from Indianapolis to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain
- Take the train from Fullerton Amtrak Station to San Diegotrain
2d 20h$1,030–2,106
Mcghee Tyson Airport (TYS) to San Diego International Airport (SAN) flights
Questions & Answers
The cheapest way to get from Knoxville to San Diego is to drive and fly which costs $190 - $750 and takes 8h 28m.
The fastest way to get from Knoxville to San Diego is to fly which takes 6h 17m and costs $290 - $1,100.
No, there is no direct bus from Knoxville to San Diego. However, there are services departing from Knoxville and arriving at San Diego via El Mezcal Grocery - Jackson, TN, Indianapolis Union Station, St Louis Bus Station and Los Angeles. The journey, including transfers, takes approximately 2 days 17h.
The distance between Knoxville and San Diego is 1922 miles. The road distance is 2168.2 miles.
The best way to get from Knoxville to San Diego without a car is to bus and train via Kansas City which takes 2 days 11h and costs $850 - $1,800.
It takes approximately 6h 17m to get from Knoxville to San Diego, including transfers.
Knoxville to San Diego bus services, operated by Wanda Coach, depart from Knoxville station.
The best way to get from Knoxville to San Diego is to fly which takes 6h 17m and costs $290 - $1,100. Alternatively, you can bus, which costs $550 - $1,100 and takes 2 days 17h.
Knoxville to San Diego bus services, operated by Wanda Coach, arrive at Jackson station.
San Diego is 3h behind Knoxville. It is currently 4:57 PM in Knoxville and 1:57 PM in San Diego.
What companies run services between Knoxville, TN, USA and San Diego, CA, USA?
Southwest Airlines, American Airlines, and United Airlines fly from Mcghee Tyson Airport (TYS) to San Diego International Airport (SAN) every 4 hours. Alternatively, you can take a vehicle from Knoxville to San Diego via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, Indianapolis, Indianapolis Union Station, St Louis Bus Station, Los Angeles Union Station, and Los Angeles in around 2d 17h.
- Website
- southwest.com
Flights from Mcghee Tyson Airport to San Diego International Airport via Nashville
- Ave. Duration
- 6h 43m
- When
- Saturday to Friday
- Estimated price
- $240–1,000
Flights from Mcghee Tyson Airport to San Diego International Airport via Dallas
- Ave. Duration
- 7h 40m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $240–1,000
Flights from Mcghee Tyson Airport to San Diego International Airport via Denver
- Ave. Duration
- 8h 35m
- When
- Every day
- Estimated price
- $250–1,100
Flights from Mcghee Tyson Airport to San Diego International Airport via Austin
- Ave. Duration
- 9h 5m
- When
- Friday
- Estimated price
- $250–1,100
- Website
- aa.com
Flights from Mcghee Tyson Airport to San Diego International Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 10m
- When
- Every day
- Estimated price
- $240–1,000
Flights from Asheville Regional Airport to San Diego International Airport via Dallas/Ft.Worth
- Ave. Duration
- 8h 41m
- When
- Every day
- Estimated price
- $170–700
- Website
- delta.com
Flights from Asheville Regional Airport to San Diego International Airport via Atlanta
- Ave. Duration
- 7h
- When
- Every day
- Estimated price
- $170–750
Flights from Asheville Regional Airport to San Diego International Airport via Minneapolis
- Ave. Duration
- 10h 2m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $200–800
- Website
- united.com
Flights from Mcghee Tyson Airport to San Diego International Airport via Denver
- Ave. Duration
- 6h 42m
- When
- Every day
- Estimated price
- $250–1,100
Flights from Asheville Regional Airport to San Diego International Airport via Denver
- Ave. Duration
- 8h 2m
- When
- Every day
- Estimated price
- $180–750
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from St. Louis to Kansas City
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $85–190
- Website
- Amtrak
Train from Kansas City to Fullerton Amtrak Station
- Ave. Duration
- 34h 52m
- Frequency
- Once daily
- Estimated price
- $550–1,200
- Website
- Amtrak
Train from Fullerton Amtrak Station to San Diego
- Ave. Duration
- 2h 26m
- Frequency
- Hourly
- Estimated price
- $30–70
- Website
- Amtrak
Train from Indianapolis to Chicago Union Station
- Ave. Duration
- 5h
- Frequency
- 3 times a week
- Estimated price
- $60–130
- Website
- Amtrak
Train from Chicago Union Station to Fullerton Amtrak Station
- Ave. Duration
- 42h 44m
- Frequency
- Once daily
- Estimated price
- $700–1,500
- Website
- Amtrak
Train from Fullerton Amtrak Station to San Diego
- Ave. Duration
- 2h 26m
- Frequency
- Hourly
- Estimated price
- $30–70
- Website
- Amtrak
- Phone
- +1 646-630-7186
- [email protected]
- Website
- Wanda Coach
Bus from Knoxville to Memphis - Summer Ave
- Ave. Duration
- 6h 30m
- Frequency
- Once daily
- Estimated price
- $55–80
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $55–80
Bus from Knoxville to Jackson
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $50–75
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $50–75
Bus from Knoxville to Jackson
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $50–75
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $50–75
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Memphis Bus Station to St Louis Bus Station
- Ave. Duration
- 5h 15m
- Frequency
- Twice daily
- Estimated price
- $40–85
- Website
- Greyhound
Bus from Indianapolis Union Station to St Louis Bus Station
- Ave. Duration
- 3h 55m
- Frequency
- Every 4 hours
- Estimated price
- $35–70
- Website
- Greyhound
Bus from St Louis Bus Station to Los Angeles Union Station
- Ave. Duration
- 40h 30m
- Frequency
- Twice daily
- Estimated price
- $280–550
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Memphis Bus Station to St Louis Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- Once daily
- Estimated price
- $45–80
- Schedules at
- Flixbus USA
- Phone
- +1 888 358 6762
- [email protected]
- Website
- Tornado Bus Company
Bus from El Mezcal Grocery - Jackson, TN to Indianapolis
- Ave. Duration
- 7h 56m
- Frequency
- 3 times a week
- Estimated price
- $80–200
- Schedules at
- Tornado Bus Company
- Adults 11-59
- $80–200
Bus from El Mezcal Grocery - Jackson, TN to Indianapolis
- Ave. Duration
- 7h 56m
- Frequency
- 3 times a week
- Estimated price
- $80–200
- Schedules at
- Tornado Bus Company
- Adults 11-59
- $80–200
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Los Angeles to San Diego
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $40–60
- Website
- Amtrak
Want to know more about travelling around United States
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More Questions & Answers
Yes, the driving distance between Knoxville to San Diego is 2168 miles. It takes approximately 34h 42m to drive from Knoxville to San Diego.
There are 1927+ hotels available in San Diego.









