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How to get fromKnoxville to San Franciscoby plane, bus, train, bus (Greyhound), or car

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There are 6 ways to get from Knoxville to San Francisco by plane, bus, train, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to San Francisco International Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to San Francisco International Airport (SFO)plane plane TYS - SFO
    7h 21m
    $236–779

  2. Bus, train

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Chicago Bus Stationbus bus
    3. Take the train from Chicago Union Station to Richmondtrain train
    2d 21h
    $957–1,916

  3. Bus

    1. Take the bus from Knoxville to Jacksonbus bus
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus
    5. Take the bus from Los Angeles Union Station to San Francisco Bus Stationbus bus
    2d 22h
    $615–1,146

  4. Drive 2,470 mi

    1. Drive from Knoxville to San Franciscocar car 2,470 mi
    39h 5m
    $451–652

  5. Fly to Oakland International Airport

    1. Fly from Mcghee Tyson Airport (TYS) to Oakland International Airport (OAK)plane plane TYS - OAK
    7h 35m
    $332–1,175

  6. Fly to Norman Y. Mineta San José International Airport, Caltrain

    1. Fly from Mcghee Tyson Airport (TYS) to Norman Y. Mineta San José International Airport (SJC)plane plane TYS - SJC
    2. Take the train from Santa Clara Caltrain Northbound to San Francisco Caltrain Northboundtrain train
    8h 47m
    $329–1,182

Mcghee Tyson Airport (TYS) to San Francisco International Airport (SFO) flights

Calendar46Weekly Planes
Duration8h 9mAverage Duration
Ticket$179Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to San Francisco.ExpandLaunch map view
  • Distance: 2,141.9 mi
  • Duration: 7h 21m

What companies run services between Knoxville, TN, USA and San Francisco, CA, USA?

American Airlines, United Airlines, and Southwest Airlines fly from Mcghee Tyson Airport (TYS) to San Francisco International Airport (SFO) every 4 hours. Alternatively, you can take a vehicle from Knoxville to San Francisco Bus Station via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, Indianapolis, Indianapolis Union Station, St Louis Bus Station, and Los Angeles Union Station in around 2d 22h.

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