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How to get fromKnoxville to Sanibelby plane, bus (Greyhound), car, taxi, shuttle, or bus

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There are 5 ways to get from Knoxville to Sanibel by plane, bus (Greyhound), car, taxi, shuttle, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Ft. Myers

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Ft. Myers (RSW)plane plane TYS - RSW
    4h 35m
    $242–762

  2. Drive 772.6 mi

    cheapest
    1. Drive from Knoxville to Sanibelcar car 772.6 mi
    13h 59m
    $141–204

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Fort Myersbus bus
    24h 29m
    $345–501

  4. Fly to Punta Gorda Airport, taxi

    1. Fly from Mcghee Tyson Airport (TYS) to Punta Gorda Airport (PGD)plane plane TYS - PGD
    2. Take the taxi from Punta Gorda Airport (PGD) to Sanibeltaxi taxi
    3h 14m
    $277–777

  5. Drive, shuttle, taxi, bus

    1. Drive from Knoxville to Hot Springscar car
    2. Take a shuttle bus from Hot Springs to Black Bear Resortshuttle bus
    3. Take the taxi from Black Bear Resort to Bristol Exit 5 Park & Ride Lottaxi taxi
    4. Take the bus from Bristol Exit 5 Park & Ride Lot to Wytheville Rural King Parking Lotbus bus
    5. Take the bus from Wytheville to Charlotte Bus Stationbus bus
    6. Take the bus from Charlotte Bus Station to Orlando Bus Stationbus bus
    7. Take the bus from Orlando Bus Station to Fort Myers Bus Stopbus bus
    27h 25m
    $476–659

Mcghee Tyson Airport (TYS) to Ft. Myers (RSW) flights

Calendar75Weekly Planes
Duration5h 13mAverage Duration
Ticket$116Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Sanibel.ExpandLaunch map view
  • Distance: 691.6 mi
  • Duration: 4h 35m

What companies run services between Knoxville, TN, USA and Sanibel, FL, USA?

Delta, American Airlines, and two other airlines fly from Mcghee Tyson Airport (TYS) to Ft. Myers (RSW) every 2 hours. Alternatively, you can take a vehicle from Knoxville to Sanibel via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, C.K. Steele Plaza Gate 16, N Monroe Street and John Knox Road, Tallahassee, and Fort Myers in around 24h 29m.

Airlines
Bus operators
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