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How to get fromKnoxville to Santa Feby plane, bus, train, car, or bus (Greyhound)

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There are 9 ways to get from Knoxville to Santa Fe by plane, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Mcghee Tyson Airport to Santa Fe Municipal Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Santa Fe Municipal Airport (SAF)plane plane TYS - SAF
    6h 19m
    $238–843

  2. Drive to Chattanooga Metropolitan Airport, fly to Santa Fe Municipal Airport

    cheapest
    1. Drive from Knoxville to Chattanooga Metropolitan Airport (CHA)car car
    2. Fly from Chattanooga Metropolitan Airport (CHA) to Santa Fe Municipal Airport (SAF)plane plane CHA - SAF
    7h 39m
    $150–553

  3. Bus, train via Dallas

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Tornado Bus Co - West Memphisbus bus
    3. Take the bus from Tornado Bus Co - West Memphis to Dallas Jeffersonbus bus
    4. Take the bus from Dallas to El Pasobus bus
    5. Take the bus from El Paso Bus Station to ABQ Alvarado Transportation Centerbus bus
    6. Take the train from Downtown Albuquerque Rail Runner Station to Santa Fe Depot Rail Runner Stationtrain train
    37h 8m
    $410–839

  4. Bus, train

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Chicago Bus Stationbus bus
    3. Take the train from Chicago Union Station to Lamy Stationtrain train
    41h 35m
    $599–1,168

  5. Drive 1,384.8 mi

    1. Drive from Knoxville to Santa Fecar car 1,384.8 mi
    21h 46m
    $253–365

  6. Drive to Asheville Regional Airport, fly to Santa Fe Municipal Airport

    1. Drive from Knoxville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Santa Fe Municipal Airport (SAF)plane plane AVL - SAF
    8h 51m
    $163–608

  7. Fly Mcghee Tyson Airport to Albuquerque International Airport, train

    1. Fly from Mcghee Tyson Airport (TYS) to Albuquerque International Airport (ABQ)plane plane TYS - ABQ
    2. Take the train from Downtown Albuquerque Rail Runner Station to Santa Fe Depot Rail Runner Stationtrain train
    9h 14m
    $273–1,077

  8. Bus

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Albuquerque Bus Stationbus bus
    5. Take the bus from Albuquerque to Santa Febus bus
    44h 28m
    $469–820

  9. Bus, train #2

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Indianapolisbus bus
    3. Take the train from Indianapolis to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Lamy Stationtrain train
    47h 32m
    $696–1,395

Mcghee Tyson Airport (TYS) to Santa Fe Municipal Airport (SAF) flights

Calendar53Weekly Planes
Duration6h 48mAverage Duration
Ticket$163Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Santa Fe.ExpandLaunch map view
  • Distance: 1,259.4 mi
  • Duration: 6h 19m

What companies run services between Knoxville, TN, USA and Santa Fe, NM, USA?

United Airlines and American Airlines fly from Mcghee Tyson Airport (TYS) to Santa Fe Municipal Airport (SAF) every 4 hours. Alternatively, you can take a vehicle from Knoxville to Sandoval @ Water IB via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, Indianapolis, Indianapolis Union Station, St Louis Bus Station, Albuquerque Bus Station, Albuquerque, and Santa Fe Place in around 44h 28m.

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