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How to get fromKnoxville to Senecaby car, plane, bus, or taxi

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There are 2 ways to get from Knoxville to Seneca by car, plane, bus, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive 150.9 mi

    best
    1. Drive from Knoxville to Senecacar car 150.9 mi
    4h 2m
    $28–40
  2. Fly, bus, taxi

    1. Fly from Mcghee Tyson Airport (TYS) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane TYS - ATL
    2. Take the bus from Atlanta to Flying J - Commercebus bus
    3. Take the taxi from Flying J - Commerce to Senecataxi taxi
    5h 55m
    $270–890

Mcghee Tyson Airport (TYS) to Hartsfield-Jackson Atlanta International Airport (ATL) flights

Calendar58Weekly Planes
Duration1h 5mAverage Duration
Ticket$72Cheapest Price
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Questions & Answers

What companies run services between Knoxville, TN, USA and Seneca, SC, USA?

You can drive from Knoxville to Seneca in around 4h 2m.

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