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How to get fromKnoxville to Sikestonby bus, car, plane, or taxi

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There are 6 ways to get from Knoxville to Sikeston by bus, car, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, drive

    best
    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Paducah Bus Stationbus bus
    3. Drive from Paducah Bus Station to Sikestoncar car
    8h 42m
    $165–221

  2. Drive  369.4 mi

    cheapest
    1. Drive from Knoxville to Sikestoncar car 369.4 mi
    6h 24m
    $66–95

  3. Fly to Barkley Regional Airport, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Barkley Regional Airport (PAH)plane plane TYS - PAH
    2. Drive from Barkley Regional Airport (PAH) to Sikestoncar car
    8h 18m
    $146–502

  4. Bus

    1. Take the bus from Knoxville to Jacksonbus bus Nyc
    2. Take the bus from El Mezcal Grocery - Jackson, TN to Tornado Bus Co - West Memphisbus bus
    3. Take the bus from Tornado Bus Co - West Memphis to Flying J - Matthewsbus bus
    12h 10m
    $212–310

  5. Fly to Nashville, bus, drive

    1. Fly from Mcghee Tyson Airport (TYS) to Nashville (BNA)plane plane TYS - BNA
    2. Take the bus from Nashville Bus Station to Paducah Bus Stationbus bus
    3. Drive from Paducah Bus Station to Sikestoncar car
    6h 44m
    $136–461

  6. Fly to Cape Girardeau Municipal Airport, taxi

    1. Fly from Mcghee Tyson Airport (TYS) to Cape Girardeau Municipal Airport (CGI)plane plane TYS - CGI
    2. Take the taxi from Cape Girardeau Municipal Airport (CGI) to Sikestontaxi taxi
    6h 48m
    $217–587

Mcghee Tyson Airport (TYS) to Barkley Regional Airport (PAH) flights

Calendar28Weekly Planes
Duration8h 54mAverage Duration
Ticket$80Cheapest Price
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Comparing Your Travel Options

Map of how to get from Knoxville to Sikeston.ExpandLaunch map view
  • Distance: 388.8 mi
  • Duration: 8h 42m

What companies run services between Knoxville, TN, USA and Sikeston, MO, USA?

You can take a vehicle from Knoxville to Sikeston via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, Tornado Bus Co - West Memphis, and Flying J - Matthews in around 12h 10m.

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