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How to get fromKnoxville to Sioux Fallsby plane, bus, or car

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There are 5 ways to get from Knoxville to Sioux Falls by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Mcghee Tyson Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Sioux Falls (FSD)plane plane TYS - FSD
    6h 21m
    $189–719

  2. Drive to Asheville Regional Airport, fly

    cheapest
    1. Drive from Knoxville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Sioux Falls (FSD)plane plane AVL - FSD
    8h 23m
    $119–484

  3. Bus

    1. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    2. Take the bus from Memphis Bus Station to Kansas Citybus bus
    3. Take the bus from Kansas City to Sioux Fallsbus bus
    32h 1m
    $352–488

  4. Drive 1,087.3 mi

    1. Drive from Knoxville to Sioux Fallscar car 1,087.3 mi
    17h 56m
    $199–287

  5. Drive to Chattanooga Metropolitan Airport, fly

    1. Drive from Knoxville to Chattanooga Metropolitan Airport (CHA)car car
    2. Fly from Chattanooga Metropolitan Airport (CHA) to Sioux Falls (FSD)plane plane CHA - FSD
    7h 58m
    $171–729

Mcghee Tyson Airport (TYS) to Sioux Falls (FSD) flights

Calendar95Weekly Planes
Duration6h 18mAverage Duration
Ticket$131Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Sioux Falls.ExpandLaunch map view
  • Distance: 881 mi
  • Duration: 6h 21m

What companies run services between Knoxville, TN, USA and Sioux Falls, SD, USA?

Delta, United Airlines, and American Airlines fly from Mcghee Tyson Airport (TYS) to Sioux Falls (FSD) hourly. Alternatively, you can take a vehicle from Knoxville to The Bus Stop via Knoxville, Memphis - Summer Ave, SUMMER AVENUE at WHITE STATION ROAD, William Hudson Transit Center, AIRWAYS BOULEVARD at BROOKS ROAD, Memphis Bus Station, Kansas City, Sioux Falls, and Maple/Career NE corner in around 32h 1m.

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