What is the cheapest way to get from Knoxville to St. Louis?

The cheapest way to get from Knoxville to St. Louis is to drive which costs $85 - $130 and takes 7h 58m.

What is the fastest way to get from Knoxville to St. Louis?

The fastest way to get from Knoxville to St. Louis is to fly which takes 4h 35m and costs $150 - $700.

Is there a direct bus between Knoxville and St. Louis?

No, there is no direct bus from Knoxville to St. Louis station. However, there are services departing from Knoxville and arriving at St Louis Bus Station via Charlotte Pike & Lellyett St Eb, Central 4Th Ave - Bay 13 and Nashville Bus Station. The journey, including transfers, takes approximately 11h 34m.

How far is it from Knoxville to St. Louis?

The distance between Knoxville and St. Louis is 434 miles. The road distance is 484 miles.

How do I travel from Knoxville to St. Louis without a car?

The best way to get from Knoxville to St. Louis without a car is to bus which takes 11h 34m and costs $170 - $260.

How long does it take to get from Knoxville to St. Louis?

It takes approximately 4h 35m to get from Knoxville to St. Louis, including transfers.

Where do I catch the Knoxville to St. Louis bus from?

Knoxville to St. Louis bus services, operated by Wanda Coach, depart from Knoxville station.

Bus or fly from Knoxville to St. Louis?

The best way to get from Knoxville to St. Louis is to fly which takes 4h 35m and costs $150 - $700. Alternatively, you can bus, which costs $170 - $260 and takes 11h 34m.

Where does the Knoxville to St. Louis bus arrive?

Knoxville to St. Louis bus services, operated by Wanda Coach, arrive at Nashville station.

What is the time difference between Knoxville and St. Louis?

St. Louis is 1h behind Knoxville. It is currently 1:13 AM in Knoxville and 12:13 AM in St. Louis.

Can I drive from Knoxville to St. Louis?

Yes, the driving distance between Knoxville to St. Louis is 484 miles. It takes approximately 7h 58m to drive from Knoxville to St. Louis.

Where can I stay near St. Louis?

There are 576+ hotels available in St. Louis.

Knoxville to St. Louis - 4 ways to travel via plane, bus, and car

How to get fromKnoxville to St. Louis

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There are 4 ways to get from Knoxville to St. Louis by plane, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly from Mcghee Tyson Airport
best
1. Fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL)plane TYS - STL
4h 35m
$155–670
Drive 481.2 mi
cheapest
1. Drive from Knoxville to St. Louiscar 481.2 mi
7h 58m
$88–127
Bus
1. Take the bus from Knoxville to Nashvillebus Nyc
2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus Greyhound US0186 / ...
11h 34m
$178–254
Drive to Chattanooga Metropolitan Airport, fly
1. Drive from Knoxville to Chattanooga Metropolitan Airport (CHA)car
2. Fly from Chattanooga Metropolitan Airport (CHA) to Lambert–St. Louis International Airport (STL)plane CHA - STL
5h 57m
$107–520

Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) flights

126Weekly Planes

5h 6mAverage Duration

$95Cheapest Price

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Comparing Your Travel Options

Map of how to get from Knoxville to St. Louis.

Launch map view

Distance: 431.1 mi
Duration: 4h 35m

What companies run services between Knoxville, TN, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a vehicle from Knoxville to St Louis Bus Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville Bus Station in around 11h 34m.

Airlines

Bus operators

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How to get fromKnoxville to St. Louisby plane, bus (Greyhound, Flixbus), or car

There are 4 ways to get from Knoxville to St. Louis by plane, bus (Greyhound, Flixbus), or car

Fly from Mcghee Tyson Airport

Drive 481.2 mi

Bus

Drive to Chattanooga Metropolitan Airport, fly