There are 3 ways to get from Knoxville to St. Louis by plane, bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL)plane TYS - STL
4h 45m$145–620Drive 481.2 mi
cheapest- Drive from Knoxville to St. Louiscar 481.2 mi
7h 58m$88–127Bus
- Take the bus from Knoxville to Nashvillebus Nyc
- Take the bus from Nashville Bus Station to St Louis Bus Stationbus Greyhound US0186 / ...
11h 34m$178–264
Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) flights
Questions & Answers
The cheapest way to get from Knoxville to St. Louis is to drive which costs $85 - $130 and takes 7h 58m.
The fastest way to get from Knoxville to St. Louis is to fly which takes 4h 45m and costs $140 - $650.
No, there is no direct bus from Knoxville to St. Louis station. However, there are services departing from Knoxville and arriving at St Louis Bus Station via Charlotte Pike & Lellyett St Eb, Central 4Th Ave - Bay 13 and Nashville Bus Station. The journey, including transfers, takes approximately 11h 34m.
The distance between Knoxville and St. Louis is 434 miles. The road distance is 484 miles.
The best way to get from Knoxville to St. Louis without a car is to bus which takes 11h 34m and costs $170 - $270.
It takes approximately 4h 45m to get from Knoxville to St. Louis, including transfers.
Knoxville to St. Louis bus services, operated by Wanda Coach, depart from Knoxville station.
The best way to get from Knoxville to St. Louis is to fly which takes 4h 45m and costs $140 - $650. Alternatively, you can bus, which costs $170 - $270 and takes 11h 34m.
Knoxville to St. Louis bus services, operated by Wanda Coach, arrive at Nashville station.
St. Louis is 1h behind Knoxville. It is currently 6:50 PM in Knoxville and 5:50 PM in St. Louis.
What companies run services between Knoxville, TN, USA and St. Louis, MO, USA?
Southwest Airlines, Delta, and two other airlines fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a vehicle from Knoxville to St Louis Bus Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville Bus Station in around 11h 34m.
- Website
- delta.com
Flights from Mcghee Tyson Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 4h 53m
- When
- Every day
- Estimated price
- $100–600
Flights from Mcghee Tyson Airport to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 5h 42m
- When
- Every day
- Estimated price
- $130–700
- Phone
- +1 646-630-7186
- [email protected]
- Website
- Wanda Coach
Bus from Knoxville to Nashville
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $40–60
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $40–60
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More Questions & Answers
Yes, the driving distance between Knoxville to St. Louis is 484 miles. It takes approximately 7h 58m to drive from Knoxville to St. Louis.
There are 555+ hotels available in St. Louis.