There are 5 ways to get from Knoxville to Syracuse by plane, bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Syracuse Hancock International Airport
best- Fly from Mcghee Tyson Airport (TYS) to Syracuse Hancock International Airport (SYR)plane TYS - SYR
5h 59m$248–1,075Drive 763.3 mi
cheapest- Drive from Knoxville to Syracusecar 763.3 mi
14h 4m$140–202Bus, train
- Take the bus from Knoxville, TN to New York, NYbus Ny
- Take the train from New York Penn Station to Syracusetrain VIA Rail
19h 8m$215–403Fly to Rochester, train
- Fly from Mcghee Tyson Airport (TYS) to Rochester (ROC)plane TYS - ROC
- Take the train from Rochester to Syracuse Regional Transportation Centertrain
6h 35m$276–1,249Fly to Ithaca Tompkins Regional Airport, bus
- Fly from Mcghee Tyson Airport (TYS) to Ithaca Tompkins Regional Airport (ITH)plane TYS - ITH
- Take the bus from Ithaca to Syracuse Bus Stationbus
7h 58m$166–632
Mcghee Tyson Airport (TYS) to Syracuse Hancock International Airport (SYR) flights
Questions & Answers
The cheapest way to get from Knoxville to Syracuse is to drive which costs $130 - $210 and takes 14h 4m.
The fastest way to get from Knoxville to Syracuse is to fly which takes 5h 59m and costs $240 - $1,100.
The distance between Knoxville and Syracuse is 684 miles. The road distance is 767.8 miles.
The best way to get from Knoxville to Syracuse without a car is to bus and train which takes 19h 8m and costs $210 - $410.
It takes approximately 5h 59m to get from Knoxville to Syracuse, including transfers.
Yes, the driving distance between Knoxville to Syracuse is 768 miles. It takes approximately 14h 4m to drive from Knoxville to Syracuse.
There are 94+ hotels available in Syracuse.
What companies run services between Knoxville, TN, USA and Syracuse, NY, USA?
United Airlines, Delta, and American Airlines fly from Mcghee Tyson Airport (TYS) to Syracuse Hancock International Airport (SYR) hourly.
- Website
- delta.com
Flights from Mcghee Tyson Airport to Syracuse Hancock International Airport via Atlanta
- Ave. Duration
- 5h 18m
- When
- Every day
- Estimated price
- $220–1,200
Flights from Mcghee Tyson Airport to Syracuse Hancock International Airport via Detroit
- Ave. Duration
- 5h 15m
- When
- Every day
- Estimated price
- $200–1,100
Flights from Mcghee Tyson Airport to Syracuse Hancock International Airport via New York La Guardia
- Ave. Duration
- 5h 48m
- When
- Every day
- Estimated price
- $210–1,100
Flights from Mcghee Tyson Airport to Rochester via Detroit
- Ave. Duration
- 4h 37m
- When
- Every day
- Estimated price
- $180–1,000
Flights from Mcghee Tyson Airport to Rochester via Atlanta
- Ave. Duration
- 4h 48m
- When
- Every day
- Estimated price
- $210–1,100
- Website
- aa.com
Flights from Mcghee Tyson Airport to Syracuse Hancock International Airport via Charlotte
- Ave. Duration
- 5h 30m
- When
- Every day
- Estimated price
- $200–1,100
Flights from Mcghee Tyson Airport to Syracuse Hancock International Airport via Reagan Washington
- Ave. Duration
- 5h 21m
- When
- Every day
- Estimated price
- $190–1,000
Flights from Mcghee Tyson Airport to Syracuse Hancock International Airport via Philadelphia
- Ave. Duration
- 7h 2m
- When
- Every day
- Estimated price
- $200–1,100
Flights from Mcghee Tyson Airport to Rochester via Reagan Washington
- Ave. Duration
- 4h 59m
- When
- Every day
- Estimated price
- $180–1,000
Flights from Mcghee Tyson Airport to Rochester via Charlotte
- Ave. Duration
- 5h 28m
- When
- Every day
- Estimated price
- $190–1,000
- Website
- united.com
Flights from Mcghee Tyson Airport to Syracuse Hancock International Airport via Washington Dulles
- Ave. Duration
- 4h 36m
- When
- Every day
- Estimated price
- $190–1,000
Flights from Mcghee Tyson Airport to Rochester via Washington Dulles
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $180–1,000
Flights from Mcghee Tyson Airport to Ithaca Tompkins Regional Airport via Washington Dulles
- Ave. Duration
- 4h 59m
- When
- Every day
- Estimated price
- $100–550
- Website
- southwest.com
Flights from Mcghee Tyson Airport to Rochester via Baltimore
- Ave. Duration
- 3h 55m
- When
- Sunday
- Estimated price
- $180–1,000
- Phone
- +1 888 842-7245
- Website
- VIA Rail
Train from New York Penn Station to Syracuse
- Ave. Duration
- 5h 33m
- Frequency
- Once daily
- Estimated price
- $75–240
- Website
- VIA Rail
- Escape
- $75–190
- Business
- $110–230
- Business Plus
- $120–240
- Economy
- $85–190
- Economy Plus
- $95–200
Train from Rochester to Syracuse Regional Transportation Center
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $21–160
- Website
- VIA Rail
- Escape
- $21–75
- Business
- $50–150
- Business Plus
- $65–160
- Economy
- $24–80
- Economy Plus
- $26–85
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Rochester to Syracuse Regional Transportation Center
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $24–55
- Website
- Amtrak
- Phone
- +1 615-939-8887
- [email protected]
- Website
- New York to Tennessee Bus
Bus from Knoxville, TN to New York, NY
- Ave. Duration
- 12h
- Frequency
- Once daily
- Estimated price
- $95–110
- Website
- New York to Tennessee Bus
- Adult One-way
- $95–110
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Ithaca to Syracuse Bus Station
- Ave. Duration
- 1h 15m
- Frequency
- 3 times a week
- Estimated price
- $9–15
- Schedules at
- Flixbus USA
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