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How to get fromKnoxville to Tupeloby plane, car, bus (Greyhound), bus, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Knoxville to Tupelo by plane, car, bus (Greyhound), bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Golden Triangle Regional Airport, drive

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Golden Triangle Regional Airport (GTR)plane plane TYS - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    5h 26m
    $143–534

  2. Drive 347.3 mi

    cheapest
    1. Drive from Knoxville to Tupelocar car 347.3 mi
    6h 23m
    $64–92

  3. Bus

    1. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    2. Take the bus from Memphis Bus Station to Tupelobus bus Greyhound US0610
    9h 58m
    $201–279

  4. Fly to Tupelo Regional Airport

    1. Fly from Mcghee Tyson Airport (TYS) to Tupelo Regional Airport (TUP)plane plane TYS - TUP
    6h 15m
    $166–635

  5. Fly to Memphis, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Memphis (MEM)plane plane TYS - MEM
    2. Take the bus from Memphis Bus Station to Tupelobus bus
    5h 44m
    $205–867

  6. Bus via Nashville

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Memphis Bus Stationbus bus
    3. Take the bus from Memphis Bus Station to Tupelobus bus
    11h 4m
    $190–283

Mcghee Tyson Airport (TYS) to Golden Triangle Regional Airport (GTR) flights

Calendar14Weekly Planes
Duration5h 48mAverage Duration
Ticket$77Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to Tupelo.ExpandLaunch map view
  • Distance: 382.1 mi
  • Duration: 5h 26m

What companies run services between Knoxville, TN, USA and Tupelo, MS, USA?

You can take a vehicle from Knoxville to Tupelo via Knoxville, Memphis - Summer Ave, Memphis Bus Station, and Tupelo in around 9h 58m. Alternatively, American Airlines, Corporate Flight Management Inc, and two other airlines fly from Mcghee Tyson Airport (TYS) to Tupelo Regional Airport (TUP) 3 times a day.

Airlines
Bus operators

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