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How to get fromKnoxville to West Lafayetteby plane, bus (Greyhound, Flixbus), car, bus, or train

Find Transport to West Lafayette

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There are 7 ways to get from Knoxville to West Lafayette by plane, bus (Greyhound, Flixbus), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Purdue University Airport

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Purdue University Airport (LAF)plane plane TYS - LAF
    6h 29m
    $153–618

  2. Drive 411.3 mi

    cheapest
    1. Drive from Knoxville to West Lafayettecar car 411.3 mi
    7h 16m
    $76–109

  3. Bus

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Lafayette Bus Stopbus bus Greyhound US0100
    13h 9m
    $183–269

  4. Fly to Indianapolis, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Indianapolis (IND)plane plane TYS - IND
    2. Take the bus from Indianapolis Airport to Purdue Memorial Unionbus bus
    5h 42m
    $195–807

  5. Fly to Chicago O'Hare International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane plane TYS - ORD
    2. Take the bus from Chicago Bus Station to Lafayette Bus Stopbus bus
    6h 10m
    $147–517

  6. Fly to Chicago Midway International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW)plane plane TYS - MDW
    2. Take the bus from Chicago Bus Station to Lafayette Bus Stopbus bus
    5h 51m
    $160–580

  7. Bus, train

    1. Take the bus from Knoxville to Nashvillebus bus Nyc
    2. Take the bus from Nashville Bus Station to Indianapolis Union Stationbus bus
    3. Take the train from Indianapolis to Lafayette Amtrak Stationtrain train
    13h 25m
    $202–274

Mcghee Tyson Airport (TYS) to Purdue University Airport (LAF) flights

Calendar47Weekly Planes
Duration7h 46mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Knoxville to West Lafayette.ExpandLaunch map view
  • Distance: 370.4 mi
  • Duration: 6h 29m

What companies run services between Knoxville, TN, USA and West Lafayette, IN, USA?

United Airlines and American Airlines fly from Mcghee Tyson Airport (TYS) to Purdue University Airport (LAF) every 4 hours. Alternatively, you can take a vehicle from Knoxville to Lafayette Bus Stop via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville Bus Station in around 13h 9m.

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