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How to get fromLa Crosse to Buffaloby plane, train (Amtrak), bus (Greyhound, Flixbus), car, bus, train, or bus (Flixbus, Greyhound)

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There are 8 ways to get from La Crosse to Buffalo by plane, train (Amtrak), bus (Greyhound, Flixbus), car, bus, train, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from La Crosse (LSE) to Buffalo Niagara International Airport (BUF)plane plane LSE - BUF
    6h 15m
    $119–624

  2. Fly to Toronto Pearson International Airport, bus

    cheapest
    1. Fly from La Crosse (LSE) to Toronto Pearson International Airport (YYZ)plane plane LSE - YYZ
    2. Take the bus from Toronto Pearson Airport to Buffalobus bus
    9h 18m
    $93–394

  3. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    17h 52m
    $206–612

  4. Bus via Chicago

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago to Clevelandbus bus
    4. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    18h 30m
    $116–237

  5. Drive  812.3 mi

    1. Drive from La Crosse to Buffalocar car 812.3 mi
    13h 43m
    $149–215

  6. Fly to Rochester, bus

    1. Fly from La Crosse (LSE) to Rochester (ROC)plane plane LSE - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 47m
    $187–812

  7. Fly to Toronto Island Airport, bus, train

    1. Fly from La Crosse (LSE) to Toronto Island Airport (YTZ)plane plane LSE - YTZ
    2. Take the bus from Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floor to Bus Terminalbus bus
    3. Take the train from Niagara Falls Amtrak Station to Buffalotrain train
    8h 44m
    $96–576

  8. Bus

    1. Take the bus from La Crosse Grand River Station to Appleton Valley Transitbus bus
    2. Take the bus from Appleton Transit Center to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Torontobus bus
    4. Take the bus from Toronto to Buffalobus bus
    26h 50m
    $156–234

La Crosse to Buffalo by train (Amtrak)

Calendar14Weekly Trains
Duration17h 52mAverage Duration
Ticket$206Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Buffalo.ExpandLaunch map view
  • Distance: 648.4 mi
  • Duration: 6h 15m

What companies run services between La Crosse, WI, USA and Buffalo, NY, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Buffalo Niagara International Airport (BUF) 3 times a day. Alternatively, you can take a train from La Crosse Amtrak Station to Buffalo via Chicago Union Station and Buffalo Depew Station in around 17h 52m.

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