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How to get fromLa Crosse to Buffaloby plane, train (Amtrak), bus (Greyhound, Flixbus), car, bus, train, or bus (Greyhound)

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There are 8 ways to get from La Crosse to Buffalo by plane, train (Amtrak), bus (Greyhound, Flixbus), car, bus, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly La Crosse to Buffalo Niagara International Airport

    best
    1. Fly from La Crosse (LSE) to Buffalo Niagara International Airport (BUF)plane plane LSE - BUF
    5h 39m
    $123–649

  2. Fly La Crosse to Toronto Pearson International Airport, bus

    cheapest
    1. Fly from La Crosse (LSE) to Toronto Pearson International Airport (YYZ)plane plane LSE - YYZ
    2. Take the bus from Toronto Pearson Airport to Buffalobus bus
    8h 46m
    $92–394

  3. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    17h 52m
    $436–826

  4. Bus via Milwaukee

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago to Clevelandbus bus
    4. Take the bus from Cleveland to Buffalobus bus
    18h 30m
    $116–238

  5. Drive  812.3 mi

    1. Drive from La Crosse to Buffalocar car 812.3 mi
    13h 43m
    $149–215

  6. Fly La Crosse to Rochester, bus

    1. Fly from La Crosse (LSE) to Rochester (ROC)plane plane LSE - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    9h 35m
    $187–862

  7. Train to Minneapolis–Saint Paul International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Buffalo Niagara International Airport (BUF)plane plane MSP - BUF
    7h 49m
    $208–890

  8. Bus

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus
    4. Take the bus from Cleveland Bus Station to Buffalobus bus
    19h 43m
    $150–258

La Crosse to Buffalo by train (Amtrak)

Calendar14Weekly Trains
Duration17h 52mAverage Duration
Ticket$436Cheapest Price
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Comparing Your Travel Options

Map of how to get from La Crosse to Buffalo.ExpandLaunch map view
  • Distance: 648.3 mi
  • Duration: 5h 39m

What companies run services between La Crosse, WI, USA and Buffalo, NY, USA?

American Airlines flies from La Crosse (LSE) to Buffalo Niagara International Airport (BUF) twice daily. Alternatively, you can take a train from La Crosse Amtrak Station to Buffalo via Chicago Union Station and Buffalo Depew Station in around 17h 52m.

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