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How to get fromLa Crosse to Charlestonby plane, train (Amtrak), bus, train, or car

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There are 6 ways to get from La Crosse to Charleston by plane, train (Amtrak), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charleston International Airport

    best
    1. Fly from La Crosse (LSE) to Charleston International Airport (CHS)plane plane LSE - CHS
    7h 53m
    $115–483

  2. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    34h 47m
    $509–1,064

  3. Bus, train

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Newark Penn Stationbus bus
    4. Take the train from Newark Penn Station to Charleston Amtrak Stationtrain train
    40h 29m
    $422–795

  4. Drive 1,153 mi

    1. Drive from La Crosse to Charlestoncar car 1,153 mi
    20h 37m
    $211–304

  5. Fly to Hilton Head Airport, drive

    1. Fly from La Crosse (LSE) to Hilton Head Airport (HHH)plane plane LSE - HHH
    2. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    7h 45m
    $131–498

  6. Bus, train via Wilmington

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Wilmingtontrain train
    4. Take the train from Wilmington to Charleston Amtrak Stationtrain train
    2d
    $579–1,227

La Crosse to Charleston by bus and train

Calendar7Weekly Services
Duration40h 29mAverage Duration
Ticket$422Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Charleston.ExpandLaunch map view
  • Distance: 992 mi
  • Duration: 7h 53m

What companies run services between La Crosse, WI, USA and Charleston, SC, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Charleston International Airport (CHS) 5 times a day. Alternatively, you can take a train from La Crosse Amtrak Station to Charleston via Chicago Union Station, Petersburg Amtrak Station, and Charleston Amtrak Station in around 34h 47m.

Airlines
Train operators
Bus operators

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