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How to get fromLa Crosse to Clevelandby plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Greyhound)

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There are 6 ways to get from La Crosse to Cleveland by plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from La Crosse

    best
    1. Fly from La Crosse (LSE) to Cleveland-Hopkins International Airport (CLE)plane plane LSE - CLE
    5h 5m
    $101–494

  2. Bus via Milwaukee

    cheapest
    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago to Clevelandbus bus
    14h 20m
    $98–178

  3. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Cleveland Amtraktrain train Floridian / ...
    12h 13m
    $334–526

  4. Drive  623.7 mi

    1. Drive from La Crosse to Clevelandcar car 623.7 mi
    10h 23m
    $114–165

  5. Train to Minneapolis–Saint Paul International Airport, fly

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Cleveland-Hopkins International Airport (CLE)plane plane MSP - CLE
    7h 2m
    $626–1,115

  6. Bus

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus
    15h 55m
    $123–206

La Crosse to Cleveland by train (Amtrak)

Calendar21Weekly Trains
Duration12h 13mAverage Duration
Ticket$334Cheapest Price
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Comparing Your Travel Options

Map of how to get from La Crosse to Cleveland.ExpandLaunch map view
  • Distance: 526.4 mi
  • Duration: 5h 5m

What companies run services between La Crosse, WI, USA and Cleveland, OH, USA?

American Airlines flies from La Crosse (LSE) to Cleveland-Hopkins International Airport (CLE) 3 times a day. Alternatively, you can take a train from La Crosse Amtrak Station to Cleveland Amtrak via Chicago Union Station in around 12h 13m.

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