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How to get fromLa Crosse to Columbiaby plane, bus (Greyhound, Flixbus), train (Amtrak), or car

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There are 4 ways to get from La Crosse to Columbia by plane, bus (Greyhound, Flixbus), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from La Crosse (LSE) to Columbia (CAE)plane plane LSE - CAE
    6h 52m
    $240–1,123

  2. Drive 1,043.4 mi

    cheapest
    1. Drive from La Crosse to Columbiacar car 1,043.4 mi
    18h 48m
    $191–275

  3. Bus

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Camdenbus bus
    5. Take the bus from Camden to Columbia, SCbus bus Nyc
    31h 51m
    $233–428

  4. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Columbia Stationtrain train Floridian
    34h 53m
    $489–1,034

La Crosse to Columbia by train (Amtrak)

Calendar7Weekly Trains
Duration34h 53mAverage Duration
Ticket$489Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Columbia.ExpandLaunch map view
  • Distance: 890.5 mi
  • Duration: 6h 52m

What companies run services between La Crosse, WI, USA and Columbia, SC, USA?

United Airlines, American Airlines, and Delta fly from La Crosse (LSE) to Columbia (CAE) every 4 hours. Alternatively, you can take a bus from La Crosse to Sumter Laurel South via Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, Atlanta Bus Station, Camden, Columbia, SC, and Broad Marley South in around 31h 51m.

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