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How to get fromLa Crosse to Denverby plane, bus (Greyhound), train (Amtrak), car, train, or bus

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There are 8 ways to get from La Crosse to Denver by plane, bus (Greyhound), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from La Crosse

    best
    1. Fly from La Crosse (LSE) to Denver (DEN)plane plane LSE - DEN
    6h 44m
    $118–571

  2. Bus to Rochester, fly

    cheapest
    1. Take the bus from La Crosse to Rochesterbus bus
    2. Fly from Rochester (RST) to Denver (DEN)plane plane RST - DEN
    9h 39m
    $109–519

  3. Bus

    1. Take the bus from La Crosse to St. Paulbus bus
    2. Take the bus from Saint Paul Union Depot to Des Moinesbus bus
    3. Take the bus from Des Moines to Denver Union Stationbus bus
    24h 20m
    $194–305

  4. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Denvertrain train California Zephyr
    25h 4m
    $705–1,138

  5. Drive  893.2 mi

    1. Drive from La Crosse to Denvercar car 893.2 mi
    15h 15m
    $163–236

  6. Train to Minneapolis–Saint Paul International Airport, fly

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Denver (DEN)plane plane MSP - DEN
    7h 28m
    $163–442

  7. Bus to Dane County Regional Airport-Truax Field, fly

    1. Take the bus from La Crosse to Madisonbus bus
    2. Fly from Dane County Regional Airport-Truax Field (MSN) to Denver (DEN)plane plane MSN - DEN
    7h 37m
    $126–515

  8. Bus via Sioux Falls

    1. Take the bus from La Crosse to Minneapolisbus bus
    2. Take the bus from Minneapolis to Sioux Fallsbus bus
    3. Take the bus from Sioux Falls to Omahabus bus
    4. Take the bus from Omaha to Denverbus bus
    26h 40m
    $301–418

La Crosse to Denver by bus

Calendar7Weekly Buses
Duration24h 20mAverage Duration
Ticket$194Cheapest Price
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Comparing Your Travel Options

Map of how to get from La Crosse to Denver.ExpandLaunch map view
  • Distance: 773 mi
  • Duration: 6h 44m

What companies run services between La Crosse, WI, USA and Denver, CO, USA?

American Airlines flies from La Crosse (LSE) to Denver (DEN) 3 times a day. Alternatively, you can take a bus from La Crosse to Denver Union Station via Saint Paul Union Depot and Des Moines in around 24h 20m.

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