What is the cheapest way to get from La Crosse to Des Moines?

The cheapest way to get from La Crosse to Des Moines is to drive which costs $40 - $65 and takes 5h.

What is the fastest way to get from La Crosse to Des Moines?

The fastest way to get from La Crosse to Des Moines is to fly which takes 4h 22m and costs $130 - $650.

Is there a direct bus between La Crosse and Des Moines?

No, there is no direct bus from La Crosse to Des Moines. However, there are services departing from La Crosse and arriving at Des Moines via Rochester and Albert Lea. The journey, including transfers, takes approximately 8h 15m.

How far is it from La Crosse to Des Moines?

The distance between La Crosse and Des Moines is 217 miles. The road distance is 240.1 miles.

How do I travel from La Crosse to Des Moines without a car?

The best way to get from La Crosse to Des Moines without a car is to bus which takes 8h 15m and costs .

How long does it take to get from La Crosse to Des Moines?

It takes approximately 4h 22m to get from La Crosse to Des Moines, including transfers.

Where do I catch the La Crosse to Des Moines bus from?

La Crosse to Des Moines bus services, operated by Jefferson Lines, depart from La Crosse station.

Bus or fly from La Crosse to Des Moines?

The best way to get from La Crosse to Des Moines is to fly which takes 4h 22m and costs $130 - $650. Alternatively, you can bus, which costs and takes 8h 15m.

Where does the La Crosse to Des Moines bus arrive?

La Crosse to Des Moines bus services, operated by Jefferson Lines, arrive at Rochester, MN station.

Can I drive from La Crosse to Des Moines?

Yes, the driving distance between La Crosse to Des Moines is 240 miles. It takes approximately 5h to drive from La Crosse to Des Moines.

How do I get a bus ticket from La Crosse to Des Moines?

Book your La Crosse to Des Moines bus tickets online with Omio.

Where can I stay near Des Moines?

There are 252+ hotels available in Des Moines.

La Crosse to Des Moines - 5 ways to travel via train, plane, bus, and car

How to get fromLa Crosse to Des Moines

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There are 5 ways to get from La Crosse to Des Moines by plane, bus, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly from La Crosse
best
1. Fly from La Crosse (LSE) to Des Moines (DSM)plane LSE - DSM
4h 22m
$135–642
Drive 238.7 mi
cheapest
1. Drive from La Crosse to Des Moinescar 238.7 mi
5h
$44–63
Bus
1. Take the bus from La Crosse to Rochester, MNbus
2. Take the bus from Rochester to Albert Leabus
3. Take the bus from Albert Lea to Des Moinesbus
8h 15m
Train to Minneapolis–Saint Paul International Airport, fly
1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain
2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Des Moines (DSM)plane MSP - DSM
5h 57m
$141–658
Train, bus
1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain Empire Builder / ...
2. Take the bus from St. Paul to Des Moinesbus Jefferson Lines 805
8h 47m
$107–174

La Crosse (LSE) to Des Moines (DSM) flights

21Weekly Planes

4h 9mAverage Duration

$103Cheapest Price

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Questions & Answers

Map of how to get from La Crosse to Des Moines.

Launch map view

Distance: 215.4 mi
Duration: 4h 22m

What companies run services between La Crosse, WI, USA and Des Moines, IA, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Des Moines (DSM) 3 times a day. Alternatively, you can take a bus from La Crosse to Des Moines via Rochester and Albert Lea in around 8h 15m.

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