There are 7 ways to get from La Crosse to Des Moines by train, bus, car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, bus
best- Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain Empire Builder / ...
- Take the bus from Saint Paul Union Depot to Des Moinesbus Greyhound US0156
8h 22m$111–179Drive 238.7 mi
cheapest- Drive from La Crosse to Des Moinescar 238.7 mi
5h$41–59Fly from La Crosse
- Fly from La Crosse (LSE) to Des Moines (DSM)plane LSE - DSM
5h 52m$96–404Train, bus via Des Moines
- Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain Empire Builder / ...
- Take the bus from St. Paul to Des Moinesbus Jefferson Lines 805
8h 47m$136–199Bus
- Take the bus from La Crosse to St. Paulbus Jefferson Lines 966
- Take the bus from St. Paul to Des Moinesbus Jefferson Lines 805
9h 20m$109–150Train to Minneapolis–Saint Paul International Airport, fly
- Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain
- Fly from Minneapolis–Saint Paul International Airport (MSP) to Des Moines (DSM)plane MSP - DSM
6h 3m$146–525Bus to Rochester, fly
- Take the bus from La Crosse to Rochesterbus
- Fly from Rochester (RST) to Des Moines (DSM)plane RST - DSM
8h 35m$97–432
La Crosse to Des Moines by train and bus
Comparing Your Travel Options
The cheapest way to get from La Crosse to Des Moines is to drive which costs $40 - $60 and takes 5h.
The fastest way to get from La Crosse to Des Moines is to drive which takes 5h and costs $40 - $60.
No, there is no direct bus from La Crosse to Des Moines. However, there are services departing from La Crosse and arriving at Des Moines via St. Paul. The journey, including transfers, takes approximately 9h 20m.
The distance between La Crosse and Des Moines is 377 miles. The road distance is 240.1 miles.
The best way to get from La Crosse to Des Moines without a car is to train and bus which takes 8h 22m and costs $110 - $180.
It takes approximately 8h 22m to get from La Crosse to Des Moines, including transfers.
La Crosse to Des Moines bus services, operated by Jefferson Lines, depart from La Crosse station.
The best way to get from La Crosse to Des Moines is to fly which takes 5h 52m and costs $95 - $410. Alternatively, you can bus, which costs $100 - $150 and takes 9h 20m.
La Crosse to Des Moines bus services, operated by Jefferson Lines, arrive at St. Paul station.
Yes, the driving distance between La Crosse to Des Moines is 240 miles. It takes approximately 5h to drive from La Crosse to Des Moines.
What companies run services between La Crosse, WI, USA and Des Moines, IA, USA?
American Airlines flies from La Crosse (LSE) to Des Moines (DSM) 3 times a day. Alternatively, you can take a bus from La Crosse to Des Moines via St. Paul in around 9h 20m.
- Website
- delta.com
Flights from Minneapolis–Saint Paul International Airport to Des Moines
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $55–390
Flights from Rochester to Des Moines via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 6h 23m
- When
- Every day
- Estimated price
- $50–330
- Website
- aa.com
Flights from La Crosse to Des Moines via Chicago O'Hare
- Ave. Duration
- 6h 28m
- When
- Every day
- Estimated price
- $60–360
Flights from Rochester to Des Moines via Chicago O'Hare
- Ave. Duration
- 6h 54m
- When
- Every day
- Estimated price
- $65–370
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from La Crosse Amtrak Station to St. Paul-Minneapolis
- Ave. Duration
- 2h 52m
- Frequency
- 3 times a day
- Estimated price
- $70–110
- Website
- Amtrak
Train from La Crosse Amtrak Station to St. Paul-Minneapolis
- Ave. Duration
- 2h 52m
- Frequency
- 3 times a day
- Estimated price
- $70–110
- Website
- Amtrak
Train from La Crosse Amtrak Station to St. Paul-Minneapolis
- Ave. Duration
- 2h 52m
- Frequency
- 3 times a day
- Estimated price
- $70–110
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Saint Paul Union Depot to Des Moines
- Ave. Duration
- 4h 30m
- Frequency
- Once daily
- Estimated price
- $40–70
- Website
- Greyhound
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from St. Paul to Des Moines
- Ave. Duration
- 4h 55m
- Frequency
- 4 times a week
- Estimated price
- $65–90
- Book at
- Jefferson Lines
- Adult
- $65–90
Bus from La Crosse to St. Paul
- Ave. Duration
- 3h 25m
- Frequency
- Once daily
- Estimated price
- $40–65
- Book at
- Jefferson Lines
- Adult
- $40–65
Bus from St. Paul to Des Moines
- Ave. Duration
- 4h 55m
- Frequency
- 4 times a week
- Estimated price
- $65–90
- Book at
- Jefferson Lines
- Adult
- $65–90
Bus from La Crosse to Rochester
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $28–40
- Book at
- Jefferson Lines
- Adult
- $28–40
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Booking & Getting There
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