There are 8 ways to get from La Crosse to Erie by plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly La Crosse to Erie International Airport
best- Fly from La Crosse (LSE) to Erie International Airport (ERI)plane LSE - ERI
5h 26m$85–403Train (Amtrak)
- Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain Empire Builder / ...
- Take the train from Chicago Union Station to Erie Stationtrain Lake Shore Limited
14h 56m$395–608Bus
- Take the bus from La Crosse to Milwaukeebus
- Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to Cleveland Bus Stationbus
- Take the bus from Cleveland Bus Station to Eriebus
17h 30m$149–224Drive 723.4 mi
- Drive from La Crosse to Eriecar 723.4 mi
12h 11m$132–191Fly La Crosse to Cleveland-Hopkins International Airport, train
- Fly from La Crosse (LSE) to Cleveland-Hopkins International Airport (CLE)plane LSE - CLE
- Take the train from Cleveland Amtrak to Erie Stationtrain
7h 40m$151–584Fly La Crosse to Buffalo Niagara International Airport, bus
- Fly from La Crosse (LSE) to Buffalo Niagara International Airport (BUF)plane LSE - BUF
- Take the bus from Buffalo to Eriebus
8h 24m$147–724Bus to Rochester, fly to Erie International Airport
- Take the bus from La Crosse to Rochesterbus
- Fly from Rochester (RST) to Erie International Airport (ERI)plane RST - ERI
11h 46m$101–471Bus, train
- Take the bus from La Crosse to Madisonbus
- Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus
- Take the train from Chicago Union Station to Erie Stationtrain
16h 44m$305–483
La Crosse to Erie by train (Amtrak)
Comparing Your Travel Options
The cheapest way to get from La Crosse to Erie is to drive which costs $130 - $200 and takes 12h 11m.
The fastest way to get from La Crosse to Erie is to fly which takes 5h 26m and costs $85 - $410.
No, there is no direct bus from La Crosse to Erie. However, there are services departing from La Crosse and arriving at Erie via Milwaukee Intermodal Station, Chicago Bus Station and Cleveland Bus Station. The journey, including transfers, takes approximately 17h 30m.
No, there is no direct train from La Crosse station to Erie station. However, there are services departing from La Crosse Amtrak Station and arriving at Erie Station via Chicago Union Station. The journey, including transfers, takes approximately 14h 56m.
The distance between La Crosse and Erie is 592 miles. The road distance is 727.6 miles.
The best way to get from La Crosse to Erie without a car is to train which takes 14h 56m and costs $390 - $650.
It takes approximately 5h 26m to get from La Crosse to Erie, including transfers.
La Crosse to Erie bus services, operated by Jefferson Lines, depart from La Crosse station.
La Crosse to Erie train services, operated by Amtrak, depart from La Crosse Amtrak Station.
The best way to get from La Crosse to Erie is to fly which takes 5h 26m and costs $85 - $410. Alternatively, you can train, which costs $390 - $650 and takes 14h 56m, you could also bus, which costs $140 - $230 and takes 17h 30m.
What companies run services between La Crosse, WI, USA and Erie, PA, USA?
American Airlines flies from La Crosse (LSE) to Erie International Airport (ERI) 3 times a week. Alternatively, you can take a train from La Crosse Amtrak Station to Erie Station via Chicago Union Station in around 14h 56m.
- Website
- aa.com
Flights from La Crosse to Erie International Airport via Chicago O'Hare
- Ave. Duration
- 4h 3m
- When
- Tuesday, Wednesday, and Saturday
- Estimated price
- $65–380
Flights from La Crosse to Cleveland-Hopkins International Airport via Chicago O'Hare
- Ave. Duration
- 5h 15m
- When
- Every day
- Estimated price
- $80–480
Flights from La Crosse to Buffalo Niagara International Airport via Chicago O'Hare
- Ave. Duration
- 4h 25m
- When
- Tuesday, Wednesday, Saturday, and Sunday
- Estimated price
- $110–650
Flights from Rochester to Erie International Airport via Chicago O'Hare
- Ave. Duration
- 6h 33m
- When
- Every day
- Estimated price
- $70–390
Flights from Rochester to Erie International Airport via Chicago O'Hare, Charlotte
- Ave. Duration
- 11h 22m
- When
- Every day
- Estimated price
- $110–550
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from La Crosse Amtrak Station to Chicago Union Station
- Ave. Duration
- 5h 8m
- Frequency
- 3 times a day
- Estimated price
- $150–240
- Website
- Amtrak
Train from Chicago Union Station to Erie Station
- Ave. Duration
- 8h 48m
- Frequency
- Twice daily
- Estimated price
- $240–370
- Website
- Amtrak
Train from Cleveland Amtrak to Erie Station
- Ave. Duration
- 1h 28m
- Frequency
- Twice daily
- Estimated price
- $50–80
- Website
- Amtrak
Train from Chicago Union Station to Erie Station
- Ave. Duration
- 8h 48m
- Frequency
- Twice daily
- Estimated price
- $240–370
- Website
- Amtrak
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from La Crosse to Milwaukee
- Ave. Duration
- 3h 50m
- Frequency
- Once daily
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
Bus from La Crosse to Rochester
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $28–40
- Book at
- Jefferson Lines
- Adult
- $28–40
Bus from La Crosse to Madison
- Ave. Duration
- 2h 20m
- Frequency
- Once daily
- Estimated price
- $35–55
- Book at
- Jefferson Lines
- Adult
- $35–55
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Milwaukee Intermodal Station to Chicago Bus Station
- Ave. Duration
- 1h 35m
- Frequency
- 4 times a day
- Estimated price
- $15–24
- Website
- Greyhound
Bus from Chicago Bus Station to Cleveland Bus Station
- Ave. Duration
- 7h 10m
- Frequency
- Twice daily
- Estimated price
- $60–95
- Website
- Greyhound
Bus from Cleveland Bus Station to Erie
- Ave. Duration
- 1h 55m
- Frequency
- Once daily
- Estimated price
- $20–30
- Website
- Greyhound
Bus from Buffalo to Erie
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $16–25
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Milwaukee Intermodal Station to Chicago Bus Station
- Ave. Duration
- 2h 15m
- Frequency
- 3 times a day
- Estimated price
- $14–21
- Schedules at
- Flixbus USA
Bus from Buffalo to Erie
- Ave. Duration
- 1h 45m
- Frequency
- 5 times a week
- Estimated price
- $14–22
- Schedules at
- Flixbus USA
- Phone
- +1 (866) 912 - 6224
- [email protected]
- Website
- Rockland Coaches
Bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton St
- Ave. Duration
- 4h
- Frequency
- Hourly
- Estimated price
- $26–60
- Schedules at
- Rockland Coaches
- Adult
- $26–60
Want to know more about travelling around United States
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Booking & Getting There
La Crosse to Erie bus services, operated by Jefferson Lines, arrive at Milwaukee station.
Erie is 1h ahead of La Crosse. It is currently 5:50 AM in La Crosse and 6:50 AM in Erie.
La Crosse to Erie train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between La Crosse to Erie is 728 miles. It takes approximately 12h 11m to drive from La Crosse to Erie.
Book your La Crosse to Erie train tickets online with Omio.
Book your La Crosse to Erie bus tickets online with Omio.
There are 49+ hotels available in Erie.










