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How to get fromLa Crosse to Great Smoky Mountainsby plane, car, bus, or train

Find Transport to Great Smoky Mountains

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There are 7 ways to get from La Crosse to Great Smoky Mountains by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly La Crosse to Mcghee Tyson Airport, drive

    best
    1. Fly from La Crosse (LSE) to Mcghee Tyson Airport (TYS)plane plane LSE - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    7h 35m
    $168–837

  2. Fly La Crosse to Asheville Regional Airport, drive

    cheapest
    1. Fly from La Crosse (LSE) to Asheville Regional Airport (AVL)plane plane LSE - AVL
    2. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    7h 16m
    $107–443

  3. Bus, drive

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Union Station to Toledobus bus
    4. Take the bus from Toledo Bus Stop to Winston Salem(Trans Center)bus bus
    5. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    6. Drive from Asheville, NC to Great Smoky Mountainscar car
    31h 39m
    $259–458

  4. Train, bus, drive

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    39h 13m
    $477–1,053

  5. Drive 862.9 mi

    1. Drive from La Crosse to Great Smoky Mountainscar car 862.9 mi
    15h 38m
    $158–228

  6. Train to Minneapolis–Saint Paul International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS)plane plane MSP - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    8h 40m
    $232–1,053

  7. Bus, drive via Columbus

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Columbusbus bus
    3. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from New Leicester Hwy at Walgreens to Great Smoky Mountainscar car
    32h 21m
    $222–383

La Crosse (LSE) to Mcghee Tyson Airport (TYS) flights

Calendar30Weekly Planes
Duration5h 49mAverage Duration
Ticket$143Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 743.4 mi
  • Duration: 7h 35m

What companies run services between La Crosse, WI, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from La Crosse to Great Smoky Mountains. However, you can take the taxi to La-Crosse-Airport-LSE airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from La Crosse to Great Smoky Mountains via Madison, 250 N. Lake St - Madison UW Campus, W Jackson Blvd, after S Clinton St, Chicago Union Station, Toledo Bus Stop, Winston Salem(Trans Center), and Asheville, NC in around 31h 39m.

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